Trelstad R L
Suppl Thromb Haemost. 1978;63:153-60.
The end of the collagen fibril is an important and unique morphological site. Growth of fibrils in vitro and in vivo appears to occur by addition of ordered subassemblies of collagen aggregates at the fibril end. In tissues the fibril end appears closely related to the cell surface in both mesenchymal cells and epithelia. In the latter cell type there is an apparent relationship between the basement membrane and fibril end. Platelets do not aggregate upon exposure to basement membranes or collagens derived therefrom. We suggest that the end of the fibril which is embedded in the outer face of the basement membrane may be involved in interaction with the platelet.
胶原纤维的末端是一个重要且独特的形态学部位。在体外和体内，纤维的生长似乎是通过在纤维末端添加有序的胶原聚集体亚组装体来实现的。在组织中，纤维末端在间充质细胞和上皮细胞中似乎都与细胞表面密切相关。在后一种细胞类型中，基底膜与纤维末端之间存在明显的关系。血小板在暴露于基底膜或从中衍生的胶原蛋白时不会聚集。我们认为，嵌入基底膜外表面的纤维末端可能参与与血小板的相互作用。
