Esquius Soriguera J, Alejo Sánchez M, Padilla Navas I, Rodríguez Casquero C, León González C
Rev Clin Esp. 1989 Oct;185(6):303-5.
A pseudomesotheliomatous adenocarcinoma, which is a rare form of peripheral pulmonary tumor with diffuse thickening of the pleural cavity mimicking a mesothelioma, and a malignant mesothelioma with a carcinoma like disseminating pattern are presented. The biopsy obtained by thoracotomy in one case, and the necropsy studies enabled the diagnosis by the microscopic pattern, the presence of mucosubstances (PAS diastase) and the immune histochemical profiles with antibodies against several antigenic groups (CEA, EMA, CAM 5.2, and Vimentin. The value of these techniques to differentiate adenocarcinomas and mesotheliomas is discussed. The presence of CEA orients to an epithelial origin of a neoplasia.
本文报告了一例假间皮瘤样腺癌，这是一种罕见的周围型肺肿瘤，表现为胸腔弥漫性增厚，类似间皮瘤；还报告了一例具有癌样播散模式的恶性间皮瘤。其中一例通过开胸手术获取活检组织，尸检研究通过显微镜下形态、黏液物质（PAS淀粉酶消化法）的存在以及针对几种抗原组的抗体（癌胚抗原、上皮膜抗原、CAM 5.2和波形蛋白）的免疫组织化学特征得以确诊。文中讨论了这些技术在鉴别腺癌和间皮瘤方面的价值。癌胚抗原的存在提示肿瘤起源于上皮。
