IRF5基因rs2070197多态性与系统性红斑狼疮的关联：一项荟萃分析。
Association of the IRF5 rs2070197 polymorphism with systemic lupus erythematosus: a meta-analysis.
作者信息
Li Yuan, Chen Si, Li Ping, Wu Ziyan, Li Jing, Liu Bin, Zhang Fengchun, Li Yongzhe
机构信息
Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China.
出版信息
Clin Rheumatol. 2015 Sep;34(9):1495-501. doi: 10.1007/s10067-015-3036-5. Epub 2015 Aug 2.
The aim of this study was to explore whether the interferon regulatory factor 5 (IRF5) gene rs2070197 polymorphism was associated with systemic lupus erythematosus (SLE) in multiple ethic populations. A meta-analysis was conducted on the C allele of the IRF5 rs2070197 polymorphism. A total of 7 published case-control studies with 12 comparisons involving 8171 SLE patients and 8904 controls were available for this meta-analysis. This meta-analysis demonstrated the IRF5 rs2070197 polymorphism conferred susceptibility to SLE in all subjects (odds ratio (OR) = 2.128, 95 % confidence interval (CI): 1.856-2.441, P < 0.001) without inter-study heterogeneity. The IRF5 rs2070197 polymorphism was identified as risk factors for SLE in Caucasian populations (OR 1.82, 95 % CI 1.70-1.96), but it had no effects (monomorphic) in Asians. Large-scale multicenter epidemiological studies in selected populations with other risk factors were urgently required.
本研究旨在探讨干扰素调节因子5（IRF5）基因rs2070197多态性是否与多个种族人群的系统性红斑狼疮（SLE）相关。对IRF5 rs2070197多态性的C等位基因进行了荟萃分析。本荟萃分析共纳入7项已发表的病例对照研究，包含12组比较，涉及8171例SLE患者和8904例对照。该荟萃分析表明，IRF5 rs2070197多态性使所有受试者对SLE易感（优势比（OR）=2.128，95%置信区间（CI）：1.856 - 2.441，P<0.001），且研究间无异质性。IRF5 rs2070197多态性被确定为白种人群中SLE的危险因素（OR 1.82，95%CI 1.70 - 1.96），但在亚洲人群中无影响（呈单态性）。迫切需要在有其他危险因素的特定人群中开展大规模多中心流行病学研究。
Zotero 插件