Department of Dermatology, Lianyungang Municipal Frist People Hospital, Lianyungang Jiangsu, China.
Int J Immunogenet. 2011 Oct;38(5):411-7. doi: 10.1111/j.1744-313X.2011.01025.x. Epub 2011 Aug 11.
To more precisely estimate the association between interferon regulatory factor 5 (IRF5) polymorphisms and systemic lupus erythematosus (SLE) risk, we surveyed studies on the association of IRF5 rs2204640, rs10954213, rs729302 or rs2280714 with SLE using PubMed, Embase and Web of Science up to February 2011. Two investigators independently assessed the data quality and extracted the data. A total of 17 comparisons from ten relevant studies involving 6403 patients and 7475 controls were included to analyse the association between IRF5 rs2004640 and SLE risk (odds ratio, OR = 1.41, 95% confidence interval (CI) 1.34-1.49, P = 0.000). As for rs10954213, there were ten comparisons from six relevant studies involving 3461 patients and 3692 controls were included to analyse the association between IRF5 rs10954213 and SLE risk (OR = 1.23, 95% CI 1.08-1.39, P = 0.002). And this meta-analysis also showed a significant association of rs729302 (OR = 0.78, 95% CI 0.74-0.83, P = 0.000), rs2280714 (OR = 0.90, 95% CI 0.83-0.98, P = 0.021) with SLE. In a subgroup analysis by ethnicity, significantly increased SLE risk was associated with IRF5 rs2004640 T allele in populations of European, Asian and Latin American origin, and the rs10954213 A allele is significantly associated with SLE in European origin but not in Asian origin. This meta-analysis suggested that IRF5 gene polymorphism was associated with SLE in multiple ethnic populations.
为了更准确地评估干扰素调节因子 5 (IRF5) 多态性与系统性红斑狼疮 (SLE) 风险之间的关联，我们检索了截至 2011 年 2 月在 PubMed、Embase 和 Web of Science 上发表的关于 IRF5 rs2204640、rs10954213、rs729302 或 rs2280714 与 SLE 关联的研究。两位研究者独立评估数据质量并提取数据。共纳入 10 项相关研究的 17 项比较，涉及 6403 例患者和 7475 例对照，以分析 IRF5 rs2004640 与 SLE 风险之间的关联（比值比，OR = 1.41，95%置信区间 [CI] 1.34-1.49，P = 0.000）。对于 rs10954213，纳入 6 项相关研究的 10 项比较，涉及 3461 例患者和 3692 例对照，以分析 IRF5 rs10954213 与 SLE 风险之间的关联（OR = 1.23，95% CI 1.08-1.39，P = 0.002）。该荟萃分析还显示 rs729302（OR = 0.78，95% CI 0.74-0.83，P = 0.000）和 rs2280714（OR = 0.90，95% CI 0.83-0.98，P = 0.021）与 SLE 显著相关。按种族亚组分析，IRF5 rs2004640 T 等位基因与欧洲、亚洲和拉丁美洲人群的 SLE 风险显著增加相关，而 rs10954213 A 等位基因与欧洲人群的 SLE 显著相关，但与亚洲人群无关。本荟萃分析表明，IRF5 基因多态性与多种族人群的 SLE 相关。
