急性血源性耐甲氧西林金黄色葡萄球菌（MRSA）骨髓炎和脓毒性关节炎的临床及血液学预测指标
Clinical and haematological predictors of acute hematogenous Methicillin Resistant Staphylococcus aureus (MRSA) osteomyelitis & septic arthritis.
作者信息
Agrawal Rahul, Sharma Deep, Dhiman Pooja, Patro Dilip Kumar
机构信息
Department of Orthopaedics, JIPMER, Puducherry 605 006, India.
Department of Biochemistry, JIPMER, Puducherry 605 006, India.
出版信息
J Orthop. 2015 Jan 29;12(3):137-41. doi: 10.1016/j.jor.2015.01.014. eCollection 2015 Sep.
INTRODUCTION
In the present study, we observed differences in the clinical and haematological parameters in patients of MRSA and non MRSA acute osteoarticular infection.
METHODOLOGY
For the patients of acute haematogenous osteomyelitis/septic arthritis, clinical features, haematological parameters and blood & aspirate cultures were recorded.
RESULTS
Of 81 patients enrolled in the study, 61 were culture positive (22% MRSA). Statistically significant difference was found only in CRP (P < 0.001). ROC curve analysis shows that CRP levels of >13.9 mg/L, MRSA bone and joint infection could be predicted with 92.9% sensitivity and 79.1% specificity (AUC = 89.1).
CONCLUSION
Estimation of serum CRP levels at the time of presentation can aid in distinguishing MRSA osteomyelitis from non MRSA one.
引言
在本研究中，我们观察了耐甲氧西林金黄色葡萄球菌（MRSA）和非MRSA急性骨关节炎感染患者的临床和血液学参数差异。
方法
对于急性血源性骨髓炎/脓毒性关节炎患者，记录其临床特征、血液学参数以及血液和抽吸物培养结果。
结果
在纳入研究的81例患者中，61例培养呈阳性（22%为MRSA）。仅在C反应蛋白（CRP）方面发现有统计学显著差异（P < 0.001）。ROC曲线分析表明，CRP水平>13.9 mg/L时，预测MRSA骨和关节感染的敏感性为92.9%，特异性为79.1%（曲线下面积[AUC]=89.1）。
结论
就诊时测定血清CRP水平有助于区分MRSA骨髓炎和非MRSA骨髓炎。
Zotero 插件