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Teratogen susceptibility of XO mothers and XO embryos in mice.

作者信息

Endo A, Watanabe T

机构信息

Department of Hygiene and Preventive Medicine, Yamagata University School of Medicine, Japan.

出版信息

Teratology. 1989 Nov;40(5):525-9. doi: 10.1002/tera.1420400515.

DOI:10.1002/tera.1420400515
PMID:2623641
Abstract

We examined whether the chromosomal imbalance inherent in an XO constitution in mice is more susceptible to teratogenic influence of biotin deficiency using a newly established mouse colony with pure X monosomy. We hypothesized that XO mothers or XO embryos might be more susceptible to certain teratogens. Contrary to our expectation, the incidence of external malformations induced by biotin deficiency did not differ either between XX dams and XO dams or between XX fetuses and XO fetuses.

摘要

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