Kirchner T, Schalke B, Marx A, Müller-Hermelink H K
Institute of Pathology, University of Würzburg, FRG.
Thymus. 1989;14(1-3):195-203.
Based on the original proposals of Müller-Hermelink [3,8] and the study of 95 tumor specimens from the files of our institute we have established a new concept for the classification of thymic epithelial tumors. Thymomas are related to the structural components of normal thymus and divided in medullary, mixed, predominantly cortical and cortical types. In addition a well-differentiated thymic carcinoma with partial loss of organotypic differentiation is characterized and distinguished from other carcinoma types with total lack of specific thymic features. Prognostic evaluation showed, that medullary and mixed thymomas are always benign tumors, whereas predominantly cortical thymomas, cortical thymomas and well-differentiated thymic carcinomas are low-grade malignant tumors with increasing invasiveness and even metastatic capacity. Moreover the proliferation rate of neoplastic epithelial cells in vitro, which was studied in 12 cases, correlated to the different tumor types and their growth behaviour in vivo.
基于米勒-赫梅林克的原始提议[3,8]以及对我院存档的95份肿瘤标本的研究，我们建立了一种新的胸腺上皮肿瘤分类概念。胸腺瘤与正常胸腺的结构成分相关，分为髓质型、混合型、以皮质为主型和皮质型。此外，还对一种具有部分器官样分化缺失的高分化胸腺癌进行了特征描述，并将其与完全缺乏特定胸腺特征的其他癌类型区分开来。预后评估显示，髓质型和混合型胸腺瘤始终为良性肿瘤，而以皮质为主型胸腺瘤、皮质型胸腺瘤和高分化胸腺癌为低级别恶性肿瘤，其侵袭性和转移能力不断增强。此外，对12例病例进行的体外肿瘤上皮细胞增殖率研究与不同肿瘤类型及其体内生长行为相关。
