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[自身免疫性肠病]

[Autoimmune enteropathy].

作者信息

Kinnunen Urpo, Vuopala Katri, Kaukinen Katri

出版信息

Duodecim. 2015;131(6):533-40.

Abstract

Autoimmune enteropathy (AIE) is characterized by protracted diarrhea, malabsorption, immunomediated damage to the intestinal mucosa, and unresponsiveness to changes in diet. The disease is mainly manifested in the small intestine. Lymphocyte deposits are present on the mucous membrane, and anti-enterocyte or anti-goblet cell antibodies have been described in the majority of affected persons. AIE occurs primarily in infants. Immunosuppressive drugs have been used with varying success. The prognosis of AlE is dependent on the degree of severity of the damage to the intestinal mucosa and extraintestinal symptoms and diseases associated therewith.

摘要

自身免疫性肠病(AIE)的特征为持续性腹泻、吸收不良、免疫介导的肠黏膜损伤以及对饮食变化无反应。该疾病主要表现在小肠。黏膜上存在淋巴细胞沉积,并且在大多数患者中已发现抗肠上皮细胞或抗杯状细胞抗体。AIE主要发生于婴儿。免疫抑制药物的使用效果不一。AIE的预后取决于肠黏膜损伤的严重程度以及与之相关的肠外症状和疾病。

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