青少年及年轻成人急性髓系白血病的治疗
Treatment of Acute Myeloid Leukemia in Adolescent and Young Adult Patients.
作者信息
Seval Guldane Cengiz, Ozcan Muhit
机构信息
Department of Hematology, Ankara University School of Medicine, Ankara 06100, Turkey.
出版信息
J Clin Med. 2015 Mar 11;4(3):441-59. doi: 10.3390/jcm4030441.
Abstract
The objectives of this review were to discuss standard and investigational treatment strategies for adolescent and young adult with acute myeloid leukemia, excluding acute promyelocytic leukemia. Acute myeloid leukemia (AML) in adolescent and young adult patients (AYAs) may need a different type of therapy than those currently used in children and older patients. As soon as AML is diagnosed, AYA patient should be offered to participate in well-designed clinical trials. The standard treatment approach for AYAs with AML is remission induction chemotherapy with an anthracycline/cytarabine combination, followed by either consolidation chemotherapy or stem cell transplantation, depending on the ability of the patient to tolerate intensive treatment and cytogenetic features. Presently, continuing progress of novel drugs targeting specific pathways in acute leukemia may bring AML treatment into a new era.
摘要
本综述的目的是讨论青少年和青年急性髓系白血病（不包括急性早幼粒细胞白血病）的标准治疗策略和研究性治疗策略。青少年和青年患者（AYA）的急性髓系白血病（AML）可能需要一种与目前用于儿童和老年患者的治疗方法不同的治疗方式。一旦确诊为AML，应让AYA患者参与精心设计的临床试验。AYA-AML的标准治疗方法是采用蒽环类药物/阿糖胞苷联合进行缓解诱导化疗，随后根据患者耐受强化治疗的能力和细胞遗传学特征进行巩固化疗或干细胞移植。目前，针对急性白血病特定通路的新型药物的不断进展可能会将AML治疗带入一个新时代。
相似文献
1
Treatment of Acute Myeloid Leukemia in Adolescent and Young Adult Patients.青少年及年轻成人急性髓系白血病的治疗
J Clin Med. 2015 Mar 11;4(3):441-59. doi: 10.3390/jcm4030441.
2
Current treatment of acute myeloid leukemia.急性髓细胞白血病的当前治疗方法。
Curr Opin Oncol. 2012 Nov;24(6):711-9. doi: 10.1097/CCO.0b013e328358f62d.
3
Outcomes of Adolescents and Young Adults With Acute Myeloid Leukemia Treated in a Single Latin American Center.拉丁美洲单一中心治疗的青少年和年轻成人急性髓细胞白血病的结果。
Clin Lymphoma Myeloma Leuk. 2018 Apr;18(4):286-292. doi: 10.1016/j.clml.2018.02.002. Epub 2018 Feb 8.
4
Current and emerging therapies for acute myeloid leukemia.急性髓系白血病的现有和新兴疗法。
Clin Ther. 2009;31 Pt 2:2349-70. doi: 10.1016/j.clinthera.2009.11.017.
5
Venetoclax Combination Treatment of Acute Myeloid Leukemia in Adolescents and Young Adult Patients.维奈克拉联合治疗青少年和年轻成人急性髓系白血病
J Clin Med. 2024 Apr 1;13(7):2046. doi: 10.3390/jcm13072046.
6
Idarubicin Dose Escalation During Consolidation Therapy for Adult Acute Myeloid Leukemia.阿柔比星剂量递增在成人急性髓系白血病巩固治疗中的应用。
J Clin Oncol. 2017 May 20;35(15):1678-1685. doi: 10.1200/JCO.2016.70.6374. Epub 2017 Apr 3.
7
Outcome of Adolescents and Young Adults Compared With Pediatric Patients With Acute Myeloid and Promyelocytic Leukemia.青少年和青年急性髓系白血病及早幼粒细胞白血病患者与儿科患者的结局比较
Clin Lymphoma Myeloma Leuk. 2017 Feb;17(2):126-132.e1. doi: 10.1016/j.clml.2016.09.011. Epub 2016 Sep 17.
8
[Acute myeloid leukemia in adolescents and young adults: from the viewpoint of pediatricians].青少年及青年急性髓系白血病：从儿科医生的视角来看
Rinsho Ketsueki. 2017;58(8):1038-1046. doi: 10.11406/rinketsu.58.1038.
9
[Acute myeloid leukemia in adolescents and young adults: from the viewpoint of physicians].[青少年及年轻成人急性髓系白血病：从医生视角看]
Rinsho Ketsueki. 2017;58(8):1047-1052. doi: 10.11406/rinketsu.58.1047.
10
Clinical management of Australian adolescents and young adults with acute lymphoblastic and myeloid leukemias: A national population-based study.澳大利亚青少年和青年急性淋巴细胞性和髓性白血病的临床管理：一项全国性基于人群的研究。
Pediatr Blood Cancer. 2018 Nov;65(11):e27349. doi: 10.1002/pbc.27349. Epub 2018 Jul 24.
引用本文的文献
1
Venetoclax Combination Treatment of Acute Myeloid Leukemia in Adolescents and Young Adult Patients.维奈克拉联合治疗青少年和年轻成人急性髓系白血病
J Clin Med. 2024 Apr 1;13(7):2046. doi: 10.3390/jcm13072046.
2
Treatment Outcomes of Adolescents Compared to Younger Pediatric Patients with Acute Myeloid Leukemia: Do They Need a Special Approach?与小儿急性髓系白血病年轻患者相比，青少年患者的治疗结果：他们需要特殊的治疗方法吗？
Cancers (Basel). 2024 Mar 14;16(6):1145. doi: 10.3390/cancers16061145.
3
RAB27B inhibits proliferation and promotes apoptosis of leukemic cells via 3-Hydroxy butyrate dehydrogenase 2 (BDH2).RAB27B 通过 3-羟基丁酸脱氢酶 2（BDH2）抑制白血病细胞的增殖并促进其凋亡。
Bioengineered. 2022 Mar;13(3):5103-5112. doi: 10.1080/21655979.2022.2036903.
4
Expression Profiles of Long Non-Coding RNA and MicroRNA-222 in Younger AML Patients.年轻急性髓系白血病患者中长链非编码RNA和微小RNA-222的表达谱
Diagnostics (Basel). 2021 Dec 30;12(1):86. doi: 10.3390/diagnostics12010086.
5
A compound combination screening approach with potential to identify new treatment options for paediatric acute myeloid leukaemia.一种具有潜在可能识别新的儿科急性髓系白血病治疗方案的复合组合筛选方法。
Sci Rep. 2020 Oct 28;10(1):18514. doi: 10.1038/s41598-020-75453-3.
6
Outcome of Acute Myeloid Leukemia in Children Adolescents and Young Adults Treated with an Uniform Protocol in Casablanca, Morocco.在摩洛哥卡萨布兰卡采用统一方案治疗的儿童、青少年和青年急性髓系白血病的治疗结果
Indian J Hematol Blood Transfus. 2019 Apr;35(2):255-259. doi: 10.1007/s12288-018-1013-2. Epub 2018 Sep 25.
7
Evaluating cytotoxic effects of recombinant fragaceatoxin C pore forming toxin against AML cell lines.评估重组草莓毒素C孔形成毒素对急性髓系白血病细胞系的细胞毒性作用。
Iran J Basic Med Sci. 2018 Sep;21(9):878-883. doi: 10.22038/IJBMS.2018.26600.6516.
8
Targeting the Proteasome in Refractory Pediatric Leukemia Cells: Characterization of Effective Cytotoxicity of Carfilzomib.针对难治性儿科白血病细胞的蛋白酶体：卡非佐米有效细胞毒性的特征。
Target Oncol. 2018 Dec;13(6):779-793. doi: 10.1007/s11523-018-0603-0.
9
Risk factors for length of stay and charge per day differ between older and younger hospitalized patients with AML.老年和年轻的 AML 住院患者的住院时间和每天费用的风险因素不同。
Cancer Med. 2018 Jun;7(6):2744-2752. doi: 10.1002/cam4.1492. Epub 2018 Apr 16.
10
ALOX5 exhibits anti-tumor and drug-sensitizing effects in MLL-rearranged leukemia.ALOX5 在 MLL 重排白血病中表现出抗肿瘤和增敏作用。
Sci Rep. 2017 May 12;7(1):1853. doi: 10.1038/s41598-017-01913-y.
本文引用的文献
1
Fertility preservation in young females with hematological malignancies.血液系统恶性肿瘤年轻女性的生育力保存。
Acta Haematol. 2014;132(3-4):400-13. doi: 10.1159/000360199. Epub 2014 Sep 10.
2
Hematopoietic stem cell transplantation in adolescents and young adults.青少年和年轻成人的造血干细胞移植。
Acta Haematol. 2014;132(3-4):313-25. doi: 10.1159/000360211. Epub 2014 Sep 10.
3
Acute myeloid leukemia in adolescents and young adults: challenging aspects.青少年和年轻成人的急性髓细胞白血病：具有挑战性的方面。
Acta Haematol. 2014;132(3-4):292-7. doi: 10.1159/000360200. Epub 2014 Sep 10.
4
Gemtuzumab ozogamicin in children and adolescents with de novo acute myeloid leukemia improves event-free survival by reducing relapse risk: results from the randomized phase III Children’s Oncology Group trial AAML0531.吉妥单抗奥唑米星用于初治急性髓系白血病儿童和青少年可通过降低复发风险提高无事件生存期：儿童肿瘤学组III期随机试验AAML0531的结果
J Clin Oncol. 2014 Sep 20;32(27):3021-32. doi: 10.1200/JCO.2014.55.3628.
5
Gemtuzumab ozogamicin with fludarabine, cytarabine, and granulocyte colony stimulating factor (FLAG-GO) as front-line regimen in patients with core binding factor acute myelogenous leukemia.柔红霉素、氟达拉滨、阿糖胞苷和粒细胞集落刺激因子（FLAG-GO）联合治疗初治核心结合因子急性髓系白血病。
Am J Hematol. 2014 Oct;89(10):964-8. doi: 10.1002/ajh.23795. Epub 2014 Jul 21.
6
Outcome of children with relapsed acute myeloid leukemia following initial therapy under the AML99 protocol.急性髓系白血病99方案初始治疗后复发的儿童患者的预后情况。
Int J Hematol. 2014 Aug;100(2):171-9. doi: 10.1007/s12185-014-1616-9. Epub 2014 Jun 25.
7
Allogeneic hematopoietic cell transplant for acute myeloid leukemia: Current state in 2013 and future directions.急性髓系白血病的异基因造血细胞移植：2013年现状与未来方向
World J Stem Cells. 2014 Apr 26;6(2):69-81. doi: 10.4252/wjsc.v6.i2.69.
8
Lenalidomide-based maintenance therapy reduces TNF receptor 2 on CD4 T cells and enhances immune effector function in acute myeloid leukemia patients.来那度胺为基础的维持治疗降低急性髓系白血病患者 CD4 T 细胞上的 TNF 受体 2 并增强免疫效应功能。
Am J Hematol. 2014 Aug;89(8):795-802. doi: 10.1002/ajh.23746. Epub 2014 May 16.
9
Final report of phase II study of sorafenib, cytarabine and idarubicin for initial therapy in younger patients with acute myeloid leukemia.索拉非尼、阿糖胞苷和伊达比星用于年轻急性髓性白血病患者初始治疗的II期研究最终报告
Leukemia. 2014 Jul;28(7):1543-5. doi: 10.1038/leu.2014.54. Epub 2014 Feb 3.
10
Outcome of adolescents and young adults with acute myeloid leukemia treated on COG trials compared to CALGB and SWOG trials.COG 临床试验中治疗的青少年和年轻成人急性髓细胞白血病的结果与 CALGB 和 SWOG 临床试验的比较。
Cancer. 2013 Dec 1;119(23):4170-9. doi: 10.1002/cncr.28344. Epub 2013 Sep 19.
Zotero 插件