血清雌酮浓度、硫酸雌酮/雌酮比值和体重指数与绝经后原发性浸润性导管癌乳腺癌患者的人表皮生长因子受体2及孕激素受体状态相关。
Serum estrone concentration, estrone sulfate/estrone ratio and BMI are associated with human epidermal growth factor receptor 2 and progesterone receptor status in postmenopausal primary breast cancer patients suffering invasive ductal carcinoma.
作者信息
Vincze Borbála, Kapuvári Bence, Udvarhelyi Nóra, Horváth Zsolt, Mátrai Zoltán, Czeyda-Pommersheim Ferenc, Kőhalmy Krisztina, Kovács Judit, Boldizsár Mariann, Láng István, Kásler Miklós
机构信息
Department of Biochemistry, National Institute of Oncology, 1122 Budapest, Ráth György u. 7-9., Hungary.
Surgical and Molecular Tumor Pathology Centre, National Institute of Oncology, Budapest, Hungary.
出版信息
Springerplus. 2015 Jul 31;4:387. doi: 10.1186/s40064-015-1171-8. eCollection 2015.
BACKGROUND
We investigated in postmenopausal women with primary breast cancer prior to surgical intervention whether, serum levels of different steroid hormones and hormonal precursors associated with tumor tissue estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2) status.
METHODS
We enrolled 1,042 patients suffering invasive ductal carcinoma undergoing surgical resection in the National Institute of Oncology, Hungary between 2003 and 2011. Serum parameters were measured by RIA/IRMA assays; tumor tissue ER, PR and HER2 status was assessed histologically. Patients were classified according to tumor receptor status. Case-case analysis subjects were categorized into four subgroups based on serum hormone concentrations in ER, PR and HER2 receptor-negative cases, respectively.
RESULTS
Serum estrone sulfate and dehydroepiandrosterone sulfate levels correlated with each other and also with serum estrone and estradiol levels. According to case-case study the odds ratios in the highest quartile were 1.517 (p = 0.0305, Ptrend = 0.0394) for androstenedione, 1.495 (p = 0.0317, Ptrend < 0.0105) for estrone and 0.654 (p = 0.0273, Ptrend < 0.0151) for estrone sulfate/estrone ratio in PR+ vs. PR- tumors. Regarding HER2 status (HER2+ vs. HER2-), the odds ratios for estrone, estrone sulfate and estrone sulfate/estrone ratio were 0.530 (p = 0.0234, Ptrend = 0.0595), 2.438 (p = 0.0042, Ptrend < 0.0066) and 3.118 (p = 0.0001, Ptrend < 0.0001) in the highest quartile, respectively. Of note significantly increased BMI associates with PR+ and ER +/PR+ status while significantly decreased BMI was observed in HER2+ cases.
CONCLUSIONS
Taken together, measurement of serum estrone and estrone sulfate concentrations prior to surgical intervention might support the individualization of regime in postmenopausal primary breast cancer patients.
背景
我们在接受手术干预前的绝经后原发性乳腺癌女性中研究了与肿瘤组织雌激素受体（ER）、孕激素受体（PR）和人表皮生长因子受体2（HER2）状态相关的不同甾体激素和激素前体的血清水平。
方法
我们纳入了2003年至2011年间在匈牙利国家肿瘤研究所接受手术切除的1042例浸润性导管癌患者。血清参数通过放射免疫分析/免疫放射分析测定；肿瘤组织的ER、PR和HER2状态通过组织学评估。患者根据肿瘤受体状态进行分类。病例-病例分析对象根据ER、PR和HER2受体阴性病例的血清激素浓度分别分为四个亚组。
结果
血清硫酸雌酮和硫酸脱氢表雄酮水平相互关联，也与血清雌酮和雌二醇水平相关。根据病例-病例研究，在PR +与PR -肿瘤中，最高四分位数中雄烯二酮的优势比为1.517（p = 0.0305，P趋势 = 0.0394），雌酮为1.495（p = 0.0317，P趋势 < 0.0105），硫酸雌酮/雌酮比值为0.654（p = 0.0273，P趋势 < 0.0151）。关于HER2状态（HER2 +与HER2 -），最高四分位数中雌酮、硫酸雌酮和硫酸雌酮/雌酮比值的优势比分别为0.530（p = 0.0234，P趋势 = 0.0595）、2.438（p = 0.0042，P趋势 < 0.0066）和3.118（p = 0.0001，P趋势 < 0.0001）。值得注意的是，BMI显著增加与PR +和ER +/PR +状态相关，而在HER2 +病例中观察到BMI显著降低。
结论
综上所述，手术干预前测量血清雌酮和硫酸雌酮浓度可能有助于绝经后原发性乳腺癌患者治疗方案的个体化。
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