Xian M S, Hayashi K, Lu J P, Awai M
Department of Pathology, Hebei Medical College, People's Republic of China.
Acta Med Okayama. 1989 Dec;43(6):345-51. doi: 10.18926/AMO/30867.
Three types of traditional Chinese herb medicine were used to treat 98 patients with advanced esophageal squamous cell carcinoma prior to surgical treatment. Forty-two patients with the same diagnosis were treated with these herbs plus cyclophosphamide (endoxan). One hundred similar patients received surgical treatment without herbs or endoxan treatment as controls. Histologic examinations of surgical specimens were made on all of these patients. Stromal lymphoid-cell infiltration and cancer tissue degeneration were more prominent in Menispernum dehuricum DC- or Chelidonium majus L-treated patients, and were less clear in patients treated with herbs plus endoxan and the controls. The antitumor action of herbs is thought to be brought about by the activation of an immunological rejection mechanism. Herbs plus endoxan may result in the masking of the immunological response of hosts without obviously damaging cancer tissues.
三种传统中药被用于在手术治疗前治疗98例晚期食管鳞状细胞癌患者。42例诊断相同的患者接受了这些中药加环磷酰胺（癌得星）的治疗。100例相似患者接受了手术治疗，未使用中药或癌得星治疗作为对照。对所有这些患者的手术标本进行了组织学检查。在蝙蝠葛或白屈菜治疗的患者中，基质淋巴细胞浸润和癌组织退变更为显著，而在接受中药加癌得星治疗的患者和对照组中则不太明显。中药的抗肿瘤作用被认为是通过激活免疫排斥机制实现的。中药加癌得星可能会掩盖宿主的免疫反应，而不会明显损伤癌组织。
