Jameel Ehtesham, Umar Tarana, Kumar Jitendra, Hoda Nasimul
Department of Chemistry, B. R. Ambedkar Bihar University, Muzaffarpur 842001, Bihar, India.
Department of Chemistry, Jamia Millia Islamia (Central University), New Delhi, 110025, India.
Chem Biol Drug Des. 2016 Jan;87(1):21-38. doi: 10.1111/cbdd.12629. Epub 2015 Sep 16.
Drug development for neurodegenerative diseases (NDs) is foremost task for the medicinal chemists in the 21st century. Coumarins are exemplary of an assorted and aptitudinally useful set of drugs. Coumarins play a momentous role in several pharmacological and medicinal aspects. Its analogues are anticipated to play a significant role in the development of new therapeutic leads for NDs. Their promising applications in the field of ND medication are exemplified by clinical candidates such as nodakenin that have been potent for demoting memory impairment. Apart from ND, clinically used anticoagulant warfarin, anticoagulant dicoumarol, and antibiotic coumermycin, novobiocin and chartesium grab the interest of researchers in coumarins. It would be worthwhile to look at the different biological processes that could cause neurodegeneration, thereby establishing a link with distinct coumarin derivatives to serve the purpose of medication. This review undertakes estimation of the wide spectrum of studies focusing coumarin to the domain of drug research for ND. Herein, we search for multitarget coumarin-based inhibitors and their scope for NDs. Future challenges in coumarin-based drug development have been discussed, and emphases have been laid on the future perspectives of coumarins as possible drugs in the future for the treatment of NDs.
神经退行性疾病（NDs）的药物研发是21世纪药物化学家的首要任务。香豆素是一类多样且具有实用价值的药物典范。香豆素在多个药理学和医学方面都发挥着重要作用。预计其类似物在神经退行性疾病新治疗先导药物的开发中发挥重要作用。它们在神经退行性疾病药物治疗领域的应用前景，可通过如紫花前胡苷等临床候选药物来例证，这些药物在减轻记忆障碍方面具有显著效果。除了神经退行性疾病，临床使用的抗凝剂华法林、双香豆素以及抗生素香豆霉素、新生霉素和查耳酮也引起了研究人员对香豆素的兴趣。研究不同的可能导致神经退行性变的生物学过程，从而将其与不同的香豆素衍生物建立联系以用于药物治疗，是很有价值之举。本综述对聚焦于香豆素在神经退行性疾病药物研究领域的广泛研究进行了评估。在此，我们探寻基于香豆素的多靶点抑制剂及其在神经退行性疾病中的应用前景。讨论了基于香豆素的药物开发面临的未来挑战，并着重阐述了香豆素作为未来可能用于治疗神经退行性疾病药物的未来前景。
