立体定向体部放疗（SBRT）用于治疗无法手术的Ⅰ期非小细胞肺癌患者。
Stereotactic body radiotherapy (SBRT) for the treatment of inoperable stage I non-small cell lung cancer patients.
作者信息
Ceniceros L, Aristu J, Castañón E, Rolfo C, Legaspi J, Olarte A, Valtueña G, Moreno M, Gil-Bazo I
机构信息
Department of Oncology, Clínica Universidad de Navarra, Pío XII 36, 31008, Pamplona, Spain.
Department of Radiation Oncology, Clínica Universidad de Navarra, Pamplona, Spain.
出版信息
Clin Transl Oncol. 2016 Mar;18(3):259-68. doi: 10.1007/s12094-015-1361-4. Epub 2015 Aug 5.
INTRODUCTION
Lung cancer is the most frequent neoplasm in humans. Surgery is considered the best therapeutic approach for stage I non-small lung cell cancer (NSCLC). However, a remarkable amount of patients are considered as inoperable. Stereotactic body radiotherapy (SBRT) has risen as an option for those patients, rendering excellent results in quality of life and survival.
MATERIALS AND METHODS
We analyzed clinical studies published between 2002 and 2015 which included SBRT as a treatment modality. Our own clinical series was analyzed as well. The patterns of failure following SBRT were investigated, together with the outcomes and the toxicity observed.
RESULTS
SBRT has proven to maintain an excellent local control. The analysis showed the tumor size and the histology as determinant factors for the response to treatment.
CONCLUSION
According to the published evidence as well as our own experience, SBRT is a safe and feasible approach for early NSCLC. Its results may be comparable with surgery treatment.
引言
肺癌是人类最常见的肿瘤。手术被认为是I期非小细胞肺癌（NSCLC）的最佳治疗方法。然而，相当数量的患者被认为无法进行手术。立体定向体部放疗（SBRT）已成为这些患者的一种选择，在生活质量和生存率方面取得了优异的效果。
材料与方法
我们分析了2002年至2015年间发表的包括SBRT作为治疗方式的临床研究。我们自己的临床系列也进行了分析。研究了SBRT后的失败模式以及观察到的结果和毒性。
结果
SBRT已被证明能保持出色的局部控制。分析表明肿瘤大小和组织学是治疗反应的决定因素。
结论
根据已发表的证据以及我们自己的经验，SBRT是早期NSCLC的一种安全可行的方法。其结果可能与手术治疗相当。
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