来自不依赖CD4的HIV-1的可溶性包膜糖蛋白三聚体在豚鼠中引发抗体依赖性细胞毒性介导抗体。
Soluble Envelope Glycoprotein Trimers from a CD4-Independent HIV-1 Elicit Antibody-Dependent Cellular Cytotoxicity-Mediating Antibodies in Guinea Pigs.
作者信息
Murray Marta K, Teran Victor A, Chapleau Jean-Philippe, Wang Baomin, Kim Su Hyon, LaBranche Celia C, Richard Jonathan, Montefiori David C, Finzi Andrés, Yuan Wen
机构信息
Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia Health System, Charlottesville, Virginia, USA.
Centre de Recherche du CHUM and Department of Microbiology, Infectiology and Immunology, Université de Montréal, Montreal, Quebec, Canada.
出版信息
J Virol. 2015 Oct;89(20):10707-11. doi: 10.1128/JVI.01642-15. Epub 2015 Aug 5.
CD4-independent HIV-1 variants can infect coreceptor-expressing cells lacking CD4. The envelope (Env) glycoproteins on these HIV-1 variants expose a coreceptor binding site that overlaps some CD4-induced (CD4i) epitopes. Reports have demonstrated that CD4i antibodies mediate antibody-dependent cellular cytotoxicity (ADCC). Here we investigated the immunogenicity of soluble Env trimers (sgp140) from a CD4-independent HIV-1 in guinea pigs and found that the sgp140 elicited ADCC-mediating antibodies. Therefore, these sgp140 might be useful in vaccine regimens aimed at eliciting ADCC responses.
不依赖CD4的HIV-1变体可以感染缺乏CD4但表达共受体的细胞。这些HIV-1变体上的包膜（Env）糖蛋白暴露出一个与一些CD4诱导（CD4i）表位重叠的共受体结合位点。报告表明，CD4i抗体介导抗体依赖性细胞毒性（ADCC）。在此，我们研究了来自不依赖CD4的HIV-1的可溶性Env三聚体（sgp140）在豚鼠中的免疫原性，发现sgp140可引发介导ADCC的抗体。因此，这些sgp140可能有助于旨在引发ADCC反应的疫苗方案。
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