促红细胞生成素在足月儿和早产儿中的应用。
Darbepoetin Administration in Term and Preterm Neonates.
作者信息
Patel Shrena, Ohls Robin K
机构信息
Division of Neonatology, Department of Pediatrics, University of Utah, 296 Chipeta Way, Salt Lake City, UT 84105, USA.
Division of Neonatology, Department of Pediatrics, University of New Mexico, MSC10 5590, 1 University of New Mexico, Albuquerque, NM 87131-0001, USA.
出版信息
Clin Perinatol. 2015 Sep;42(3):557-66. doi: 10.1016/j.clp.2015.04.016. Epub 2015 May 23.
Abstract
Erythropoiesis-stimulating agents (ESAs) such as erythropoietin have been studied as red cell growth factors in preterm and term infants for more than 20 years. Recent studies have evaluated darbepoetin (Darbe, a long-acting ESA) for both erythropoietic effects and potential neuroprotection. We review clinical trials of Darbe in term and preterm infants, which have reported significant erythropoietic uses and neuroprotective effects. ESAs show great promise in decreasing or eliminating transfusions, and in preventing and treating brain injury in term and preterm infants.
摘要
促红细胞生成素等促红细胞生成剂（ESAs）作为红细胞生长因子，在早产儿和足月儿中已被研究了20多年。最近的研究评估了达贝泊汀（Darbe，一种长效促红细胞生成素）的促红细胞生成作用和潜在的神经保护作用。我们回顾了达贝泊汀在足月儿和早产儿中的临床试验，这些试验报告了其显著的促红细胞生成用途和神经保护作用。促红细胞生成剂在减少或消除输血以及预防和治疗足月儿和早产儿脑损伤方面显示出巨大的前景。
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