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[吡唑醇和因卡赞对大鼠旋转行为的影响]

[The effect of pyrazidol and inkazan on the rotation behavior of rats].

作者信息

Mashkovskiĭ M D, Bogdanov M B, Bondarenko N A

出版信息

Farmakol Toksikol. 1989 Nov-Dec;52(6):29-32.

PMID:2625142
Abstract

Effect of some MAO inhibitors on rotational behavior induced by d-amphetamine in unilaterally 6-OHDA-lesioned rats was studied. Among all MAO inhibitors tested only 1-deprenyl induced rotational behavior. Nialamide, chlorgiline, pyrazidol and inkazan dose-dependently enhanced rotational behavior induced by 2 mg/kg i. p. d-amphetamine and pargiline depressed it. Nialamide and inkazan greatly enhanced rotational behavior induced by 0.5 mg/kg i. p. d-amphetamine. It is suggested that nialamide and inkazan may have similar effects on DA-ergic neurotransmission.

摘要

研究了某些单胺氧化酶（MAO）抑制剂对单侧6-羟基多巴胺（6-OHDA）损伤大鼠中由右旋苯丙胺诱导的旋转行为的影响。在所有测试的MAO抑制剂中，只有司来吉兰诱导了旋转行为。尼亚酰胺、氯吉兰、吡唑醇和因卡赞剂量依赖性地增强了腹腔注射2mg/kg右旋苯丙胺诱导的旋转行为，而优降宁则抑制了这种行为。尼亚酰胺和因卡赞极大地增强了腹腔注射0.5mg/kg右旋苯丙胺诱导的旋转行为。提示尼亚酰胺和因卡赞可能对多巴胺能神经传递有相似的作用。

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