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Telomere length predicts progression and overall survival in chronic lymphocytic leukemia: data from the UK LRF CLL4 trial.

作者信息

Strefford J C, Kadalayil L, Forster J, Rose-Zerilli M J J, Parker A, Lin T T, Heppel N, Norris K, Gardiner A, Davies Z, Gonzalez de Castro D, Else M, Steele A J, Parker H, Stankovic T, Pepper C, Fegan C, Baird D, Collins A, Catovsky D, Oscier D G

机构信息

Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.

Genetic Epidemiology and Bioinformatics, Faculty of Medicine, University of Southampton, Southampton, UK.

出版信息

Leukemia. 2015 Dec;29(12):2411-4. doi: 10.1038/leu.2015.217. Epub 2015 Aug 10.

DOI:10.1038/leu.2015.217
PMID:26256637
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4676082/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62cd/4676082/be76564388ef/emss-64503-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62cd/4676082/be76564388ef/emss-64503-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62cd/4676082/be76564388ef/emss-64503-f0001.jpg

相似文献

[1]
Telomere length predicts progression and overall survival in chronic lymphocytic leukemia: data from the UK LRF CLL4 trial.

Leukemia. 2015-12

[2]
Telomere length and heavy-chain mutation status in familial chronic lymphocytic leukemia.

Leuk Res. 2002-9

[3]
Impact of telomere length on the outcome of allogeneic stem cell transplantation for poor-risk chronic lymphocytic leukaemia: results from the GCLLSG CLL3X trial.

Br J Haematol. 2017-10

[4]
Telomere length and telomerase levels delineate subgroups of B-cell chronic lymphocytic leukemia with different biological characteristics and clinical outcomes.

Haematologica. 2011-9-20

[5]
Telomeres and prognosis in patients with chronic lymphocytic leukaemia.

Int J Hematol. 2011-1-5

[6]
CLLU1 expression has prognostic value in chronic lymphocytic leukemia after first-line therapy in younger patients and in those with mutated IGHV genes.

Haematologica. 2012-8-16

[7]
The clinical significance of NOTCH1 and SF3B1 mutations in the UK LRF CLL4 trial.

Blood. 2012-10-18

[8]
Prognostic factors in chronic lymphocytic leukaemia.

Haematologica. 1999-6

[9]
ATM mutation rather than BIRC3 deletion and/or mutation predicts reduced survival in 11q-deleted chronic lymphocytic leukemia: data from the UK LRF CLL4 trial.

Haematologica. 2014-4

[10]
Mutational status of the TP53 gene as a predictor of response and survival in patients with chronic lymphocytic leukemia: results from the LRF CLL4 trial.

J Clin Oncol. 2011-4-11

引用本文的文献

[1]
The role of telomeres in leukemic stem cells function.

Regen Ther. 2025-7-8

[2]
The Telomere Length Signature in Leukemias-From Molecular Mechanisms Underlying Telomere Shortening to Immunotherapeutic Options Against Telomerase.

Cancers (Basel). 2025-6-10

[3]
Telomere biology: from disorders to hematological diseases.

Front Oncol. 2023-5-19

[4]
Role of telomere length in human carcinogenesis (Review).

Int J Oncol. 2023-7

[5]
Evolution of TP53 abnormalities during CLL disease course is associated with telomere length changes.

BMC Cancer. 2022-2-3

[6]
Chromothripsis in Chronic Lymphocytic Leukemia: A Driving Force of Genome Instability.

Front Oncol. 2021-11-26

[7]
Telomere Dysfunction in Chronic Lymphocytic Leukemia.

Front Oncol. 2021-1-15

[8]
Effect of DNA repair inhibitor AsiDNA on the incidence of telomere fusion in crisis.

Hum Mol Genet. 2021-4-26

[9]
Prognostic models for newly-diagnosed chronic lymphocytic leukaemia in adults: a systematic review and meta-analysis.

Cochrane Database Syst Rev. 2020-7-31

[10]
Chronic Lymphocytic Leukemia.

Cold Spring Harb Perspect Med. 2021-2-1

本文引用的文献

[1]
Telomere dysfunction accurately predicts clinical outcome in chronic lymphocytic leukaemia, even in patients with early stage disease.

Br J Haematol. 2014-7-3

[2]
ATM mutation rather than BIRC3 deletion and/or mutation predicts reduced survival in 11q-deleted chronic lymphocytic leukemia: data from the UK LRF CLL4 trial.

Haematologica. 2014-4

[3]
Short telomere length is associated with NOTCH1/SF3B1/TP53 aberrations and poor outcome in newly diagnosed chronic lymphocytic leukemia patients.

Am J Hematol. 2013-6-20

[4]
Biallelic ATM inactivation significantly reduces survival in patients treated on the United Kingdom Leukemia Research Fund Chronic Lymphocytic Leukemia 4 trial.

J Clin Oncol. 2012-10-22

[5]
The clinical significance of NOTCH1 and SF3B1 mutations in the UK LRF CLL4 trial.

Blood. 2012-10-18

[6]
Telomere dysfunction and its role in haematological cancer.

Br J Haematol. 2012-1-11

[7]
Mutational status of the TP53 gene as a predictor of response and survival in patients with chronic lymphocytic leukemia: results from the LRF CLL4 trial.

J Clin Oncol. 2011-4-11

[8]
Telomeres and prognosis in patients with chronic lymphocytic leukaemia.

Int J Hematol. 2011-1-5

[9]
Telomere dysfunction and fusion during the progression of chronic lymphocytic leukemia: evidence for a telomere crisis.

Blood. 2010-6-10

[10]
Prognostic factors identified three risk groups in the LRF CLL4 trial, independent of treatment allocation.

Haematologica. 2010-5-29

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