Khoobehi B, Peyman G A, Niesman M R, Oncel M
LSU Eye Center, Louisiana State University Medical Center School of Medicine, New Oreleans 70112.
Jpn J Ophthalmol. 1989;33(4):405-12.
Experiments were performed to quantitate the delivery of two drugs into the eye following hyperthermia. The drugs, cytosine arabinoside and 5-fluorouridine, were encapsulated in temperature-sensitive liposomes. After systemic injection of the liposome-encapsulated drug, microwave hyperthermia was applied to the superior limbus of rabbit eyes in an attempt to locally release the drug. Samples of aqueous humor and vitreous showed significantly higher drug levels in the heated versus the unheated eyes. Histology of the heated eyes showed no significant damage to ocular structures at the power level used to release the entrapped drug. Heating at higher power levels did damage the eye, confirming earlier studies. The potential uses and limitations of this drug delivery modality are discussed.
进行了实验以定量两种药物在热疗后进入眼睛的情况。这两种药物，阿糖胞苷和5-氟尿苷，被包裹在温度敏感脂质体中。在全身注射脂质体包裹的药物后，对兔眼的角膜缘进行微波热疗，试图使药物局部释放。房水和玻璃体样本显示，与未加热的眼睛相比，加热的眼睛中药物水平显著更高。在用于释放包封药物的功率水平下，加热眼睛的组织学检查显示眼结构没有明显损伤。在更高功率水平下加热确实会损伤眼睛，这证实了早期的研究。讨论了这种药物递送方式的潜在用途和局限性。
