Opt Lett. 2015 Aug 1;40(15):3568-71. doi: 10.1364/OL.40.003568.
In this Letter, photoacoustic-guided Raman spectroscopy (PARS) is proposed for a fast depth-resolved Raman measurement with accurate depth localization. The approach was experimentally demonstrated to receive both photoacoustic and Raman signals from a three-layer agar phantom based on a developed synergic photoacoustic-Raman probe, showing strong depth correlation and achieving magnitude of faster operation speed due to photoacoustic time-of-flight measurement and guidance, compared with the conventional depth-resolved Raman spectroscopy method. In addition, further combination with advanced optical-focusing techniques in biological-scattering medium could potentially enable the proposed approach for cancer diagnostics with both tight and fast optical focusing at the desired depth of tumor.
在这封信件中，提出了光声引导的拉曼光谱（PARS）用于快速深度分辨拉曼测量和准确深度定位。该方法通过基于协同光声-拉曼探头的三层琼脂模型进行了实验验证，结果表明，与传统的深度分辨拉曼光谱方法相比，该方法由于光声飞行时间测量和引导，具有很强的深度相关性和更快的操作速度。此外，进一步结合生物散射介质中的先进光学聚焦技术，可能使该方法能够用于癌症诊断，实现在肿瘤期望深度的紧密和快速光学聚焦。
