Koc Sevgi, Tapisiz Omer Lutfi, Turan Taner, Ocalan Reyhan, Ozfuttu Ahmet, Boran Nurettin, Kose Mehmet Faruk, Tulunay Hakki Gokhan
J Exp Ther Oncol. 2015;11(1):11-6.
The aim of this study was to analyze the patients with malignant transformation (MT) arising in mature cystic teratoma of the ovary (MCTO) and evaluate the clinicopathologic features, managements, and prognosis of these cases. The records of the patients with MT arising in MCTO who were treated at our hospital were reviewed retrospectively. The demographic features, presenting symptoms, preoperative ultrasonographic evaluations, surgical treatments, pathological findings, adjuvant therapies, follow-up outcomes, and survival time were examined. Eighteen patients with MT arising in MCTO were detected during the study period. The incidence rate of MT was 0.404% of all MCTO and squamous cell carcinoma was the most common histologic type (66.7%). The median age of the patients was 48 (range, 28-79) and the mean tumor size was 12 cm. Eleven patients (61.1%) were classified as stage IA, 1 (5.6%) as stage IC, 1 (5.6%) as stage IIC, 4 (22.2%) as stage IIIC, and the remaining 1 (5.6%) as stage IV. The overall 5-year survival rate was 66.7%. MT of MCTO is a rare occurrence entity and early detection and complete surgical staging are cardinal for survival. Additionally, this malignancy usually occurs in postmenopausal women and the high tumor diameter may be associated with MT.
本研究旨在分析卵巢成熟囊性畸胎瘤（MCTO）发生恶性转化（MT）的患者，并评估这些病例的临床病理特征、治疗方法及预后。回顾性分析我院收治的MCTO发生MT患者的病历资料。研究其人口统计学特征、临床表现、术前超声评估、手术治疗、病理结果、辅助治疗、随访结果及生存时间。研究期间共检测到18例MCTO发生MT的患者。MT的发生率占所有MCTO的0.404%，其中鳞状细胞癌是最常见的组织学类型（66.7%）。患者的中位年龄为48岁（范围28 - 79岁），平均肿瘤大小为12 cm。11例（61.1%）患者被归类为IA期，1例（5.6%）为IC期，1例（5.6%）为IIC期，4例（22.2%）为IIIC期，其余1例（5.6%）为IV期。总体5年生存率为66.7%。MCTO的MT是一种罕见的情况，早期发现和完整的手术分期是生存的关键。此外，这种恶性肿瘤通常发生在绝经后女性，肿瘤直径较大可能与MT有关。
