爱泼斯坦-巴尔病毒编码的小RNA 1（EBER-1）可预测鼻咽癌的良好预后。
Epstein-Barr virus-encoded small RNA 1 (EBER-1) could predict good prognosis in nasopharyngeal carcinoma.
作者信息
Zeng Z, Fan S, Zhang X, Li S, Zhou M, Xiong W, Tan M, Zhang W, Li G
机构信息
Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, 410013, Hunan, China.
Key Laboratory of Carcinogenesis of Ministry of Health and Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Cancer Research Institute, Central South University, Changsha, 410078, Hunan, China.
出版信息
Clin Transl Oncol. 2016 Feb;18(2):206-11. doi: 10.1007/s12094-015-1354-3. Epub 2015 Aug 11.
PURPOSE
EBER-1 (a non-coding RNA transcribed by EBV) expression was detected in most of Epstein-Barr virus (EBV)-positive nasopharyngeal carcinoma (NPC) patients. However, the relevance between EBER-1 expression and NPC clinical outcome has not been reported. This study aims to assess the possible correlations of EBER-1 expression and clinical parameters and its potential prognostic predictive ability in NPC patient's outcomes.
METHODS
We examined EBER-1 mRNA expression in 301 NPC and 130 non-NPC tissues using in situ hybridization and did statistics.
RESULTS
EBER-1 expression was up-regulated in NPC tissues when compared to non-NPC tissues. A receiver operating characteristic analysis revealed that EBER-1 expression could distinguish non-cancerous patients from NPC patients (p < 0.001, sensitivity: 72.5 %, specificity: 83.5 %, AUC = 0.815). A survival analysis revealed that patients with high levels of EBER-1 expression had a significantly good prognosis (Disease-free survival: p = 0.019, overall survival: p = 0.006).
CONCLUSION
These results indicated that EBER-1 expression is a potential prognosis factor of NPC and highly negative correlated with the progress of NPC.
目的
在大多数爱泼斯坦-巴尔病毒（EBV）阳性鼻咽癌（NPC）患者中检测到EBER-1（一种由EBV转录的非编码RNA）表达。然而，EBER-1表达与NPC临床结局之间的相关性尚未见报道。本研究旨在评估EBER-1表达与临床参数之间的可能相关性及其在NPC患者预后中的潜在预测能力。
方法
我们使用原位杂交检测了301例NPC组织和130例非NPC组织中EBER-1 mRNA的表达并进行了统计分析。
结果
与非NPC组织相比，NPC组织中EBER-1表达上调。受试者工作特征分析显示，EBER-1表达可区分非癌患者和NPC患者（p < 0.001，敏感性：72.5%，特异性：83.5%，AUC = 0.815）。生存分析显示，EBER-1表达水平高的患者预后明显良好（无病生存期：p = 0.019，总生存期：p = 0.006）。
结论
这些结果表明，EBER-1表达是NPC的一个潜在预后因素，且与NPC的进展呈高度负相关。
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