TLR4/MyD88表达在乳腺癌中的意义
Significance of TLR4/MyD88 expression in breast cancer.
作者信息
Chen Xiangjin, Zhao Feng, Zhang Huihao, Zhu Youzhi, Wu Kunlin, Tan Guozheng
机构信息
Department of Thyroid and Breast Surgery, First Affiliated Hospital of Fujian Medical University China.
Fujian Medical University Graduate School China.
出版信息
Int J Clin Exp Pathol. 2015 Jun 1;8(6):7034-9. eCollection 2015.
OBJECTIVE
To investigate the expression of TLR4/MyD88 in breast cancer, and explore the relationship between their expression and breast cancer tumor growth and invasion.
METHODS
We examined the protein expression of TLR4 and MyD88 in 60 cases of histologically confirmed breast cancer. The relationship of their protein expressions with clinical features including age at diagnosis, tumor size and stage, lymph node metastasis and distant metastasis were analyzed.
RESULTS
The IHC results showed that TLR4 and MyD88 were expressed in 63.3% (38/60) and 58.3% (35/60) of malignant breast tumors respectively. TLR4 expression in breast cancer were significantly higher than in fibroadenoma (n = 4, 20.0%) and adjacent normal tissues (n = 2, 10.0%) (P < 0.001). MyD88 expression in breast cancer were also significantly higher than in fibroadenoma (n = 4, 20.0%) and adjacent normal tissue (n = 3, 15.0%) (P < 0.001). The gene expressions of TLR4 and MyD88 were significantly higher in breast cancer than in fibroadenoma and adjacent normal tissues (P < 0.05). The protein expressions of TLR4 and MyD88 were also significantly associated with poor clinical features (P < 0.05).
CONCLUSION
TLR4 and MyD88 expression might be associated with breast cancer growth and regional and distant metastases.
目的
研究TLR4/MyD88在乳腺癌中的表达情况，并探讨其表达与乳腺癌肿瘤生长及侵袭之间的关系。
方法
我们检测了60例经组织学确诊的乳腺癌中TLR4和MyD88的蛋白表达。分析了它们的蛋白表达与包括诊断时年龄、肿瘤大小和分期、淋巴结转移及远处转移等临床特征之间的关系。
结果
免疫组化结果显示，TLR4和MyD88分别在63.3%（38/60）和58.3%（35/60）的乳腺恶性肿瘤中表达。乳腺癌中TLR4的表达显著高于纤维腺瘤（n = 4，20.0%）和癌旁正常组织（n = 2，10.0%）（P < 0.001）。乳腺癌中MyD88的表达也显著高于纤维腺瘤（n = 4，20.0%）和癌旁正常组织（n = 3，15.0%）（P < 0.001）。乳腺癌中TLR4和MyD88的基因表达显著高于纤维腺瘤和癌旁正常组织（P < 0.05）。TLR4和MyD88的蛋白表达也与不良临床特征显著相关（P < 0.05）。
结论
TLR4和MyD88的表达可能与乳腺癌的生长及局部和远处转移有关。
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