急性冠状动脉综合征患者单核细胞亚群的变化及其与心肌损伤标志物的相关性
Changes of monocyte subsets in patients with acute coronary syndrome and correlation with myocardial injury markers.
作者信息
Zhu Li, Yin Yigang, Zhou Ruifang, Lin Jie, Li Jianming, Ye Jun
机构信息
Department of Laboratory Medicine, Taizhou People's Hospital Taizhou 225300, Jiangsu Province, China.
Taizhou Polytechnic College Taizhou, China.
出版信息
Int J Clin Exp Pathol. 2015 Jun 1;8(6):7266-71. eCollection 2015.
Abstract
OBJECTIVE
To explore the changes of peripheral blood monocytes subsets in acute coronary syndrome (ACS) and its clinical significance.
METHODS
A total of 68 ACS patients and 27 healthy subjects (HS) were enrolled. Monocyte subset analysis was performed using flow cytometry: CD14++CD16-(Mon1), CD14++CD16+ (Mon2), and CD14+CD16++ (Mon3).
RESULTS
- The number of Mon1 and Mon3 were significantly increased in ACS patients compared with HS (P<0.05) and Mon2 decreased in ACS patients (P<0.05). 2. The number of Mon1, Mon2, Mon3 was positively correlated with WBC count (P<0.05). The Mon2% was negatively correlated with the serum levels of LDH, CK, CK-MB (P<0.05). The number of Mon1, Mon3 was positively correlated with the serum levels of LDH, CK, CK-MB (P<0.05).
CONCLUSION
The changes in different subsets of monocytes may be associated with pathogenesis of ACS and myocardial injury. The findings might be useful in the assessment of myocardial injury.
摘要
目的
探讨急性冠状动脉综合征（ACS）患者外周血单核细胞亚群的变化及其临床意义。
方法
纳入68例ACS患者和27名健康对照者（HS）。采用流式细胞术进行单核细胞亚群分析：CD14++CD16-（Mon1）、CD14++CD16+（Mon2）和CD14+CD16++（Mon3）。
结果
- 与HS相比，ACS患者的Mon1和Mon3数量显著增加（P<0.05），Mon2数量减少（P<0.05）。2. Mon1、Mon2、Mon3数量与白细胞计数呈正相关（P<0.05）。Mon2%与血清乳酸脱氢酶（LDH）、肌酸激酶（CK）、肌酸激酶同工酶（CK-MB）水平呈负相关（P<0.05）。Mon1、Mon3数量与血清LDH、CK、CK-MB水平呈正相关（P<0.05）。
结论
单核细胞不同亚群的变化可能与ACS的发病机制及心肌损伤有关。这些发现可能有助于评估心肌损伤。
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