Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA; Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA.
Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA; Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA.
Cancer Cell. 2015 Aug 10;28(2):149-50. doi: 10.1016/j.ccell.2015.07.011.
Molecular studies of intra-tumor heterogeneity (ITH) are revealing a large amount of DNA-based variation in many individual tumors. In a recent publication by Yates and colleagues, the ITH of breast tumors was examined and shown to have important implications for the development of resistant disease, metastasis, and clinical sequencing efforts.
肿瘤内异质性（ITH）的分子研究揭示了许多个体肿瘤中存在大量基于 DNA 的变异。在 Yates 及其同事最近的一篇论文中，研究了乳腺癌肿瘤的 ITH，并表明其对耐药性疾病的发展、转移和临床测序工作具有重要意义。
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