Zheng Yuan-qiang, Naguib Youssef W, Dong Yixuan, Shi Yan-chun, Bou Shorgan, Cui Zhengrong
Inner Mongolia Key Laboratory of Molecular Biology, Inner Mongolia Medical University, Hohhot 010059, China.
Expert Rev Vaccines. 2015;14(9):1255-75.
Bacillus Calmette-Guerin (BCG) vaccines are attenuated live strains of Mycobacterium bovis and are among the most widely used vaccines in the world. BCG is proven to be effective in preventing severe infant meningitis and miliary tuberculosis. Intravesical instillation of BCG is also a standard treatment for non-muscle invasive bladder cancer. In the past few decades, recombinant BCG (rBCG) technology had been extensively applied to develop vaccine candidates for a variety of infectious diseases, including bacterial, viral, and parasite infections, and to improve the efficacy of BCG in bladder cancer therapy. This review is intended to show the vast applications of BCG and recombinant BCG (rBCG) in the prevention of infectious diseases and cancer immunotherapy, with a special emphasis on recent approaches and trends on both pre-clinical and clinical levels.
卡介苗(BCG)是减毒活牛分枝杆菌菌株,是世界上使用最广泛的疫苗之一。卡介苗已被证明可有效预防严重的婴儿脑膜炎和粟粒性肺结核。膀胱内灌注卡介苗也是非肌层浸润性膀胱癌的标准治疗方法。在过去几十年中,重组卡介苗(rBCG)技术已被广泛应用于开发针对多种传染病(包括细菌、病毒和寄生虫感染)的候选疫苗,并提高卡介苗在膀胱癌治疗中的疗效。本综述旨在展示卡介苗和重组卡介苗(rBCG)在预防传染病和癌症免疫治疗中的广泛应用,特别强调临床前和临床水平的最新方法和趋势。