Lee Kelly A, Goetting Valerie S, Tell Lisa A
1 Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, 1 Shields Ave., Davis, California 95616, USA.
J Wildl Dis. 2015 Oct;51(4):860-7. doi: 10.7589/2014-04-093. Epub 2015 Aug 17.
Changes in inflammatory marker concentrations or activity can be used to monitor health and disease condition of domestic animals but have not been applied with the same frequency to wildlife. We measured concentrations or activity of six inflammatory markers (ceruloplasmin, haptoglobin, mannan-binding lectin-dependent complement [MBL/complement], unsaturated iron-binding capacity (UIBC) and total iron-binding capacity (TIBC), and plasma iron) in apparently healthy and sick or injured Red-tailed Hawks (Buteo jamaicensis). Haptoglobin and ceruloplasmin activities were consistently elevated in sick or injured hawks (2.1 and 2.5 times higher, respectively), and plasma iron concentrations decreased (0.46 times lower), relative to those of healthy birds. There were no differences between healthy and unhealthy hawks in TIBC and UIBC concentrations or MBL/complement activity. Therefore, haptoglobin, ceruloplasmin, and plasma iron would be useful inclusions in a panel of inflammatory markers for monitoring health in raptors.
炎症标志物浓度或活性的变化可用于监测家畜的健康和疾病状况，但在野生动物中的应用频率却不尽相同。我们测量了明显健康以及患病或受伤的红尾鵟（Buteo jamaicensis）体内六种炎症标志物（铜蓝蛋白、触珠蛋白、甘露聚糖结合凝集素依赖性补体[MBL/补体]、不饱和铁结合能力[UIBC]和总铁结合能力[TIBC]以及血浆铁）的浓度或活性。与健康鸟类相比，患病或受伤的鵟体内触珠蛋白和铜蓝蛋白的活性持续升高（分别高出2.1倍和2.5倍），而血浆铁浓度降低（低0.46倍）。健康和不健康的鵟在TIBC和UIBC浓度或MBL/补体活性方面没有差异。因此，触珠蛋白、铜蓝蛋白和血浆铁将有助于纳入炎症标志物组，用于监测猛禽的健康状况。
