Zhu Lan, Chen Gang, Zhang Weijie, Guo Hui, Lin Zhengbin, Du Dunfeng, Chen Song, Shi Huibo, Liu Shenwei, Chen Zhishui
Clin Transpl. 2014:231-4.
Kidney tubular damage caused by ischemia-reperfusion injury is considered the major cause of delayed graft function (DGF) after renal transplantation. It is not clear whether early generated de novo donor specific antibodies (DSA) play a role in DGF. Here, we report 2 cases of renal transplant with DGF, which seems to be associated with de novo DSA. When the early produced de novo DSA are not potent enough to mediate acute rejection, they may cause mild intra-graft injury, which has a significant impact on the degree of DGF and its recovery. Antibody-targeted therapy seems to be beneficial to the recovery of patients with DGF.
缺血再灌注损伤导致的肾小管损伤被认为是肾移植后移植肾功能延迟恢复（DGF）的主要原因。早期产生的新生供者特异性抗体（DSA）是否在DGF中起作用尚不清楚。在此，我们报告2例发生DGF的肾移植病例，这似乎与新生DSA有关。当早期产生的新生DSA不足以介导急性排斥反应时，它们可能会引起轻度的移植物内损伤，这对DGF的程度及其恢复有重大影响。抗体靶向治疗似乎有利于DGF患者的恢复。
