Temnikova I V, Onuchina E V, Subbotina M V, Kozlova N A
Eksp Klin Gastroenterol. 2015(3):21-5.
to study the clinical and laboratory features of chronic rhinosinusitis (CRS) associated with gastroesophageal reflux disease (GERD).
The study involved 87 patients with complaints of difficulty in nasal breathing and 30 healthy volunteers with no pathology ENT and GERD. The diagnosis of CRS met the criteria EPOS 2012. Diagnosis of GERD was performed based on the recommendations of the Montreal consensus. All investigated conducted a survey for the presence of esophageal and extraesophageal manifestations of GERD, fibroesophagogastroduodenoscopy, LOR examination with the use of endoscopes, rhinoscopy, laryngoscopy, computed tomography of the paranasal sinuses, pH-metry mucous secretions of the nose and pharynx using visual test - strips, microbiological examination of discharge from the middle of the nose stroke. Association of CRS with GERD with GERD compared with impaired nasal breathing inflammatory and non-inflammatory genesis in the absence of GERD and healthy volunteers accompanied by a large variety and frequency of symptoms, endoscopic signs of laryngitis back, reducing the pH of the pharynx, the change in quantitative and qualitative characteristics of the microflora of the nasal mucosa and paranasal sinuses.
研究与胃食管反流病（GERD）相关的慢性鼻 - 鼻窦炎（CRS）的临床和实验室特征。
该研究纳入了87例有鼻呼吸困难主诉的患者以及30名无耳鼻喉科和GERD病变的健康志愿者。CRS的诊断符合2012年欧洲鼻窦炎和鼻息肉意见书（EPOS）标准。GERD的诊断依据蒙特利尔共识的建议进行。所有受试者均接受了GERD食管和食管外表现的调查、纤维食管胃十二指肠镜检查、使用内窥镜进行的咽喉反流（LOR）检查、鼻镜检查、喉镜检查、鼻窦计算机断层扫描、使用视觉测试条对鼻和咽的黏液分泌物进行pH测定、对中鼻道分泌物进行微生物学检查。将CRS与GERD的关联与无GERD的鼻呼吸障碍性炎症性和非炎症性病因以及健康志愿者进行比较，后者伴有大量且频繁的症状、喉炎的内镜征象、咽部pH值降低、鼻黏膜和鼻窦微生物群数量和质量特征的变化。
