Meng Fei, Cao Junming, Meng Xianzhong
Department of Spine Surgery, The Third Hospital of Hebei Medical University, 139 Ziqiang Road, Shijiazhuang, Hebei 050051, The People's Republic of China.
Department of Spine Surgery, The Third Hospital of Hebei Medical University, 139 Ziqiang Road, Shijiazhuang, Hebei 050051, The People's Republic of China.
J Clin Neurosci. 2015 Dec;22(12):1862-6. doi: 10.1016/j.jocn.2015.03.065. Epub 2015 Aug 15.
The aim of this study was to determine the risk factors for postoperative infection after spinal surgery, in order to prevent its occurrence. We searched the Pubmed, Embase, and Cochrane library databases, and identified 25 case-control studies. The pooled results revealed that the major factors associated with infection were diabetes mellitus (odds ratio [OR] 2.04; 95% confidence interval [CI] 1.69-2.46), obesity (OR 2.13; 95% CI 1.55-2.93), smoking (OR 1.17; 95% CI 1.03-1.32), urinary tract infection (OR 3.19; 95% CI 1.68-6.06), hypertension (OR 1.67; 95% CI 1.26-2.22), transfusion (OR 3.64; 95% CI 2.60-5.08), and cerebrospinal fluid leak (OR 3.22; 95% CI 1.07-9.67). There was insufficient evidence to suggest that male sex, age, alcohol use, and steroid use increased the incidence of infection after spinal surgery. Our analyses suggest strategies to prevent surgical site infection. However, the results should be interpreted with caution because of heterogeneity amongst the included studies.
本研究旨在确定脊柱手术后感染的危险因素，以预防其发生。我们检索了PubMed、Embase和Cochrane图书馆数据库，共纳入25项病例对照研究。汇总结果显示，与感染相关的主要因素包括糖尿病（比值比[OR]2.04；95%置信区间[CI]1.69 - 2.46）、肥胖（OR 2.13；95%CI 1.55 - 2.93）、吸烟（OR 1.17；95%CI 1.03 - 1.32）、尿路感染（OR 3.19；95%CI 1.68 - 6.06）、高血压（OR 1.67；95%CI 1.26 - 2.22）、输血（OR 3.64；95%CI 2.60 - 5.08）和脑脊液漏（OR 3.22；95%CI 1.07 - 9.67）。没有足够的证据表明男性、年龄、饮酒和使用类固醇会增加脊柱手术后感染的发生率。我们的分析提出了预防手术部位感染的策略。然而，由于纳入研究之间存在异质性，对结果的解释应谨慎。
