中亚眼镜蛇（Naja naja oxiana Eichwald）毒液细胞毒素与磷脂酶D的相互作用。
Interaction of central Asian cobra (Naja naja oxiana Eichwald) venom cytotoxins with phospholipase D.
作者信息
Khole V
出版信息
Indian J Biochem Biophys. 1989 Aug;26(4):275-7.
PMID:2628264
Abstract
Effect of cytotoxins from the venom of Naja naja oxiana Eichwald on the hydrolytic function of phospholipase D has been further analysed. Cytotoxins in the absence of Ca2+ activated the enzyme, whereas in its presence they inhibited it. Inhibition is shown to be related to the interaction of cytotoxins with the enzyme which blocks the absorption of the enzyme at the surface of the substrate phase. Synergism in the action of cytotoxin and phospholipase D was not noticed.
摘要
对中亚眼镜蛇毒液中的细胞毒素对磷脂酶D水解功能的影响进行了进一步分析。在没有Ca2+的情况下，细胞毒素激活了该酶，而在有Ca2+的情况下则抑制了该酶。结果表明，抑制作用与细胞毒素与酶的相互作用有关，这种相互作用阻碍了酶在底物相表面的吸附。未观察到细胞毒素与磷脂酶D作用的协同效应。
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