Alsbou Mohammed, Alzubiedi Sameh, Alzobi Hamed, Samhadanah Nawal Abu, Alsaraireh Yousef, Alrawashdeh Omar, Aqel Amin, Al-Salem Khalil
Department of Pharmacology, Faculty of Medicine, Mutah University, Al-Karak, Jordan.
Department of Clinical Pharmacy and Biopharmaceutics, Faculty of Pharmacy, Jordan University, Amman, Jordan.
Int J Clin Pharm. 2015 Dec;37(6):1188-93. doi: 10.1007/s11096-015-0185-1. Epub 2015 Aug 19.
Adverse drug reactions (ADRs) represent a major health care problem.
To identify the most common ADRs, drugs implicated in ADRs, and to assess their causality, severity, preventability and risk factors predisposing to reported ADRs in Jordan.
Al-Karak teaching hospital, southern of Jordan. Method A cross sectional observational study was carried out for 11 months from January to November 2013. Suspected ADRs were recorded in ADRs report forms and analyzed for causality, severity, and preventability.
Most common ADRs, drugs involved in these ADRs, causality, severity, and preventability of suspected ADRs.
A total of 64 reports were received. Some patients suffered more than one ADR. The total number of ADRs identified was 108. Forty one drugs were involved in causing these ADRs. About 2/3 of adverse reactions (73.4 %) did not cause admission to the hospital, whereas 26.6 % of the ADRs resulted in admission. Majority of the ADRs were type A (62.5 %). Most of ADRs (92.2 %) were assessed as probable. Nearly, 65.6 % of ADRs were categorized as mild. Majority of ADRs were assessed as "not preventable" (75 %). The most common classes of drugs involved in ADRs were antibiotics, analgesics, vaccines and antiepileptics. The most commonly identified ADRs were abdominal pain, skin rash, shortness of breath, fever, upper gastrointestinal bleeding and vomiting. Risk factors contributed to ADRs were age and polypharmacy.
Jordanian healthcare providers should be aware of the importance of detecting and reporting ADRs, in order to prevent and reduce the incidence of ADRs. Awareness of risk factors predisposing to ADRs may help in identifying patients with higher risk and therefore reducing the risk of these ADRs and improving patient outcome.
药物不良反应（ADR）是一个重大的医疗保健问题。
确定约旦最常见的药物不良反应、引发药物不良反应的药物，并评估其因果关系、严重程度、可预防性以及导致报告的药物不良反应的危险因素。
约旦南部的卡拉克教学医院。方法：于2013年1月至11月进行了为期11个月的横断面观察性研究。疑似药物不良反应记录在药物不良反应报告表中，并对其因果关系、严重程度和可预防性进行分析。
最常见的药物不良反应、涉及这些药物不良反应的药物、疑似药物不良反应的因果关系、严重程度和可预防性。
共收到64份报告。一些患者出现了不止一种药物不良反应。确定的药物不良反应总数为108例。有41种药物导致了这些药物不良反应。约三分之二的不良反应（73.4%）未导致患者住院，而26.6%的药物不良反应导致患者住院。大多数不良反应为A型（62.5%）。大多数药物不良反应（92.2%）被评估为很可能。近65.6%的药物不良反应被归类为轻度。大多数药物不良反应被评估为“不可预防”（75%）。涉及药物不良反应的最常见药物类别是抗生素、镇痛药、疫苗和抗癫痫药。最常发现的药物不良反应是腹痛、皮疹、呼吸急促、发热、上消化道出血和呕吐。导致药物不良反应的危险因素是年龄和联合用药。
约旦的医疗保健提供者应意识到检测和报告药物不良反应的重要性，以预防和减少药物不良反应的发生率。了解导致药物不良反应的危险因素可能有助于识别高危患者，从而降低这些药物不良反应的风险并改善患者预后。
