咪喹莫特——其在皮肤恶性肿瘤治疗中的作用。
Imiquimod - Its role in the treatment of cutaneous malignancies.
作者信息
Bubna Aditya Kumar
机构信息
Assistant Professor, Department of Dermatology, Sri Ramachandra University, Porur, Chennai, Tamil Nadu, India.
出版信息
Indian J Pharmacol. 2015 Jul-Aug;47(4):354-9. doi: 10.4103/0253-7613.161249.
Abstract
Imiquimod is a synthetic imidazoquinolone amine, which has potent immune response modifier activity, when topically used. This characteristic property of imiquimod has led to its use in a number of applications in dermatology, particularly in cutaneous malignancies, where it has been found to be effective and safe. Currently, additional mechanisms for its activity in actinic keratosis, basal cell carcinoma, and invasive squamous cell carcinoma have been elucidated. Its usage for cutaneous metastasis in breast cancer has been a further addition to its therapeutic armamentarium recently.
摘要
咪喹莫特是一种合成的咪唑喹啉胺，局部使用时具有强大的免疫反应调节活性。咪喹莫特的这一特性使其在皮肤科的多种应用中得到使用，尤其是在皮肤恶性肿瘤方面，已发现其有效且安全。目前，其在光化性角化病、基底细胞癌和浸润性鳞状细胞癌中的作用机制已得到阐明。其在乳腺癌皮肤转移方面的应用是最近其治疗手段的又一补充。
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