DuBois Jonathan M, Rousset Olivier G, Rowley Jared, Porras-Betancourt Manuel, Reader Andrew J, Labbe Aurelie, Massarweh Gassan, Soucy Jean-Paul, Rosa-Neto Pedro, Kobayashi Eliane
Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, 3801 University Street, Room 786, Montreal, Quebec, H3A 2B4, Canada.
The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, USA.
Eur J Nucl Med Mol Imaging. 2016 Jan;43(1):152-162. doi: 10.1007/s00259-015-3167-6. Epub 2015 Aug 21.
Metabotropic glutamate receptor type 5 (mGluR5) is a G protein-coupled receptor that has been implicated in several psychiatric and neurological diseases. The radiopharmaceutical [(11)C]ABP688 allows for in vivo quantification of mGluR5 availability using positron emission tomography (PET). In this study, we aimed to detail the regional distribution of [(11)C]ABP688 binding potential (BPND) and the existence of age/sex effects in healthy individuals.
Thirty-one healthy individuals aged 20 to 77 years (men, n = 18, 45.3 ± 18.2 years; females, n = 13, 41.5 ± 19.6 years) underwent imaging with [(11)C]ABP688 using the high-resolution research tomograph (HRRT). We developed an advanced partial volume correction (PVC) method using surface-based analysis in order to accurately estimate the regional variation of radioactivity. BPND was calculated using the simplified reference tissue model, with the cerebellum as the reference region. Surface-based and volume-based analyses were performed for 39 cortical and subcortical regions of interest per hemisphere.
We found the highest [(11)C]ABP688 BPND in the lateral prefrontal and anterior cingulate cortices. The lowest [(11)C]ABP688 BPND was observed in the pre- and post-central gyri as well as the occipital lobes and the thalami. No sex effect was observed. Associations between age and [(11)C]ABP688 BPND without PVC were observed in the right amygdala and left putamen, but were not significant after multiple comparisons correction.
The present results highlight complexities underlying brain adaptations during the aging process, and support the notion that certain aspects of neurotransmission remain stable during the adult life span.
代谢型谷氨酸受体5（mGluR5）是一种G蛋白偶联受体，与多种精神和神经疾病有关。放射性药物[(11)C]ABP688可利用正电子发射断层扫描（PET）对mGluR5的可用性进行体内定量分析。在本研究中，我们旨在详细描述[(11)C]ABP688结合潜能（BPND）的区域分布以及健康个体中年龄/性别的影响。
31名年龄在20至77岁之间的健康个体（男性18名，年龄45.3±18.2岁；女性13名，年龄41.5±19.6岁）使用高分辨率研究断层扫描仪（HRRT）进行[(11)C]ABP688成像。我们开发了一种基于表面分析的先进部分容积校正（PVC）方法，以准确估计放射性的区域变化。使用简化参考组织模型计算BPND，以小脑作为参考区域。对每个半球的39个皮质和皮质下感兴趣区域进行基于表面和基于体积的分析。
我们发现[(11)C]ABP688的BPND在外侧前额叶和前扣带回皮质中最高。在中央前回和中央后回以及枕叶和丘脑中观察到[(11)C]ABP688的BPND最低。未观察到性别影响。在未进行PVC的情况下，右侧杏仁核和左侧壳核中观察到年龄与[(11)C]ABP688 BPND之间的关联，但在多次比较校正后不显著。
本研究结果突出了衰老过程中大脑适应性的潜在复杂性，并支持神经传递的某些方面在成年期保持稳定的观点。
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