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转座元件与卫星DNA之间的结构和功能联系。

Structural and functional liaisons between transposable elements and satellite DNAs.

作者信息

Meštrović Nevenka, Mravinac Brankica, Pavlek Martina, Vojvoda-Zeljko Tanja, Šatović Eva, Plohl Miroslav

机构信息

Ruđer Bošković Institute, Bijenička 54, HR-10000, Zagreb, Croatia.

出版信息

Chromosome Res. 2015 Sep;23(3):583-96. doi: 10.1007/s10577-015-9483-7.

Abstract

Transposable elements (TEs) and satellite DNAs (satDNAs) are typically identified as major repetitive DNA components in eukaryotic genomes. TEs are DNA segments able to move throughout a genome while satDNAs are tandemly repeated sequences organized in long arrays. Both classes of repetitive sequences are extremely diverse, and many TEs and satDNAs exist within a genome. Although they differ in structure, genomic organization, mechanisms of spread, and evolutionary dynamics, TEs and satDNAs can share sequence similarity and organizational patterns, thus indicating that complex mutual relationships can determine their evolution, and ultimately define roles they might have on genome architecture and function. Motivated by accumulating data about sequence elements that incorporate features of both TEs and satDNAs, here we present an overview of their structural and functional liaisons.

摘要

转座元件(TEs)和卫星DNA(satDNAs)通常被认为是真核生物基因组中的主要重复DNA成分。TEs是能够在整个基因组中移动的DNA片段,而satDNAs是串联重复序列,以长阵列形式排列。这两类重复序列极其多样,一个基因组中存在许多TEs和satDNAs。尽管它们在结构、基因组组织、传播机制和进化动态方面存在差异,但TEs和satDNAs可以共享序列相似性和组织模式,因此表明复杂的相互关系可以决定它们的进化,并最终确定它们在基因组结构和功能上可能发挥的作用。基于关于兼具TEs和satDNAs特征的序列元件的累积数据,我们在此概述它们的结构和功能联系。

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