乙醇摄入是否会干扰糖化血红蛋白的评估？

Does ethanol intake interfere with the evaluation of glycated hemoglobins?

作者信息

Ben G, Dal Fabbro S, Mongillo A, Pellegrini P, Fedele D

机构信息

1 Divisione Medica, Presidio Ospedaliero U.L.S.S. no 3, Belluno, Italy.

出版信息

Acta Diabetol Lat. 1989 Oct-Dec;26(4):337-43. doi: 10.1007/BF02624646.

DOI:10.1007/BF02624646

PMID:2629451

Abstract

Ethanol and/or its metabolites interfere with the chromatographic assay of glycated hemoglobins. Fasting plasma glucose, blood ethanol, HbA(1), HbA(1c), HbA(1a+b), MCV and GGT were determined in 22 control subjects; 22 alcoholics, 22 diabetic patients and 22 alcoholic diabetic patients. Fasting plasma glucose and all hemoglobin fractions were lower in alcoholic subjects and, except for HbA(1a+b), higher in diabetic patients and in alcoholic diabetic patients. HbA(1), and HbA(1c) correlated well with plasma glucose but not with blood ethanol, MCV and GGT. Glycated hemoglobin was not found to be a useful marker for alcohol abuse. With the chromatographic method we used, the evaluation of glycated hemoglobin fractions, chiefly HbA(1c), confirms its usefulness in monitoring the metabolic control of diabetic subjects, even in case of ethanol abuse.

摘要

乙醇和/或其代谢产物会干扰糖化血红蛋白的色谱分析。对22名对照受试者、22名酗酒者、22名糖尿病患者和22名酗酒糖尿病患者测定了空腹血糖、血液乙醇、HbA(1)、HbA(1c)、HbA(1a + b)、平均红细胞体积(MCV)和γ-谷氨酰转移酶(GGT)。酗酒受试者的空腹血糖和所有血红蛋白组分较低，除HbA(1a + b)外，糖尿病患者和酗酒糖尿病患者的这些指标较高。HbA(1)和HbA(1c)与血糖相关性良好，但与血液乙醇、MCV和GGT无关。糖化血红蛋白并非酒精滥用的有用标志物。使用我们采用的色谱法，对糖化血红蛋白组分（主要是HbA(1c)）的评估证实了其在监测糖尿病患者代谢控制方面的有用性，即使在存在乙醇滥用的情况下也是如此。