Yeo B, Lee J, Alagappan U, Pan J Y
National Skin Centre, Singapore.
Clin Exp Dermatol. 2016 Apr;41(3):272-4. doi: 10.1111/ced.12726. Epub 2015 Aug 24.
Melioidosis is caused by the saprophytic gram-negative bacillus Burkholderia pseudomallei, and has varied presentations, with cutaneous manifestations occurring in about 13% of cases. The usual histopathological features of melioidosis are suppurative to chronic granulomatous inflammation. Recommended treatment of melioidosis is sequential use of intravenous followed by oral antibiotics for a few months, although oral antibiotics alone can be used in primary cutaneous melioidosis. We report a case of cutaneous melioidosis in a healthy young man, with the unusual histopathological feature of lymphoplasmacytic inflammation, and failing an initial trial of oral antibiotics alone.
类鼻疽是由腐生革兰氏阴性杆菌伯克霍尔德菌引起的，其表现多样，约13%的病例会出现皮肤表现。类鼻疽通常的组织病理学特征是化脓性至慢性肉芽肿性炎症。类鼻疽的推荐治疗方法是先静脉使用抗生素，随后口服抗生素，持续数月，不过原发性皮肤类鼻疽也可单独使用口服抗生素。我们报告了一例健康年轻男性的皮肤类鼻疽病例，其具有不寻常的淋巴浆细胞性炎症组织病理学特征，且单独口服抗生素的初始试验失败。
