晚期氟化的绿色方法：在乙醇和水中进行（18）F标记放射性药物的放射性合成。
Green approaches to late-stage fluorination: radiosyntheses of (18)F-labelled radiopharmaceuticals in ethanol and water.
作者信息
Stewart Megan N, Hockley Brian G, Scott Peter J H
机构信息
Department of Medicinal Chemistry, College of Pharmacy, The University of Michigan, Ann Arbor, MI 48109, USA.
出版信息
Chem Commun (Camb). 2015 Oct 11;51(79):14805-8. doi: 10.1039/c5cc05919d. Epub 2015 Aug 24.
PMID:26300287
Abstract
Green strategies for late-stage fluorination with (18)F, in which ethanol and water are the only solvents used throughout the entire radiolabeling process (azeotropic drying, nucleophilic fluorination, purification and formulation), have been developed and applied to the radiosyntheses of a range of radiopharmaceuticals commonly employed in clinical PET imaging.
摘要
使用¹⁸F进行后期氟化的绿色策略已经得到开发，并应用于一系列临床PET成像中常用放射性药物的放射性合成。在整个放射性标记过程（共沸干燥、亲核氟化、纯化和制剂）中，乙醇和水是仅使用的溶剂。
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