通过亲核取代对邻-carborane 进行[18F]氟化：开发用于制备 18F 标记 BNCT 候选药物的多功能平台。
[18F]fluorination of o-carborane via nucleophilic substitution: towards a versatile platform for the preparation of 18F-labelled BNCT drug candidates.
机构信息
Radiochemistry Department, Molecular Imaging Unit, CIC biomaGUNE, Paseo Miramón 182, Parque Tecnológico de San Sebastian, 20009, San Sebastian, Spain.
出版信息
Chem Commun (Camb). 2013 Dec 21;49(98):11491-3. doi: 10.1039/c3cc46695g.
PMID:24175318
Abstract
The mono-[(18)F]fluorination of o-carborane via nucleophilic substitution is reported. The new radiochemical transformation uses cyclotron produced [(18)F]F(-) and a carboranyl iodonium salt. Further derivatization of the (18)F-labelled carborane is achieved by formation of the C(c)-lithio salt and reaction with an aldehyde.
摘要
报道了通过亲核取代反应对邻-carborane 进行单[（18）F]氟化。这种新的放射性化学转化使用回旋加速器产生的[（18）F]F-和 carboranyl 碘翁盐。通过形成 C(c)-锂盐并与醛反应，进一步对（18）F 标记的 carborane 进行衍生化。
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