生育三烯酚的生物活性研究。

Studies on the biological activity of tocotrienols.

作者信息

Komiyama K, Iizuka K, Yamaoka M, Watanabe H, Tsuchiya N, Umezawa I

出版信息

Chem Pharm Bull (Tokyo). 1989 May;37(5):1369-71. doi: 10.1248/cpb.37.1369.

DOI:10.1248/cpb.37.1369

Abstract

Tocotrienols were evaluated for activity against transplantable murine tumors inoculated i.p. into mouse, and the activities of two tocotrienols and alpha-tocopherols were compared. When the compounds were injected i.p., alpha- and gamma-tocotrienols were effective against sarcoma 180, Ehrlich carcinoma, and IMC carcinoma, and gamma-tocotrienol showed a slight life-prolonging effect in mice with Meth A fibrosarcoma, but the tocotrienols had no antitumor activity against P388 leukemia at doses of 5-40 mg/kg/d. On the other hand alpha-tocopherol had only a slight effect against sarcoma 180 and IMC carcinoma. The antitumor activity of gamma-tocotrienol was higher than that of alpha-tocotrienol. Tocotrienols showed growth inhibition of human and mouse tumor cells when the cells were exposed to these agents for 72 h in vitro, whereas tocopherol did not show any marked cytotoxic activity. Alpha- and gamma-tocotrienols had inhibitory effects on lipid peroxidation of murine microsomes by adriamycin.

摘要

对生育三烯酚针对经腹腔接种到小鼠体内的可移植性鼠肿瘤的活性进行了评估，并比较了两种生育三烯酚和α-生育酚的活性。当通过腹腔注射这些化合物时，α-和γ-生育三烯酚对肉瘤180、艾氏癌和IMC癌有效，并且γ-生育三烯酚对患有甲基胆蒽A纤维肉瘤的小鼠有轻微的延长寿命作用，但在5-40mg/kg/天的剂量下，生育三烯酚对P388白血病没有抗肿瘤活性。另一方面，α-生育酚对肉瘤180和IMC癌只有轻微作用。γ-生育三烯酚的抗肿瘤活性高于α-生育三烯酚。当人及小鼠肿瘤细胞在体外暴露于这些试剂72小时时，生育三烯酚表现出对其生长的抑制作用，而生育酚未表现出任何明显的细胞毒性活性。α-和γ-生育三烯酚对阿霉素诱导的小鼠微粒体脂质过氧化有抑制作用。