Rinnov Anders R, Rathcke Camilla N, Bonde Lisbeth, Vilsbøll Tina, Knop Filip K
The Centre of Inflammation and Metabolism, The Centre for Physical Activity Research, Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Department of Endocrinology and Metabolism, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark.
J Reprod Immunol. 2015 Nov;112:68-72. doi: 10.1016/j.jri.2015.06.092. Epub 2015 Jul 14.
Gestational diabetes mellitus (GDM) is characterised by hyperglycaemia during pregnancy. The clinical circumstances involved in the development of GDM leaves the patient at a high risk of the subsequent development of type 2 diabetes. Plasma levels of the inflammation marker YKL-40 are elevated in type 2 diabetes and correlate with fasting plasma glucose levels and insulin resistance in patients with type 2 diabetes. With the present study we aimed to determine if pregnancy (and associated insulin resistance) with or without GDM affects plasma YKL-40 levels. Plasma from women diagnosed with GDM and healthy normal glucose-tolerant pregnant women (non-GDM) was obtained at the third trimester of pregnancy and again 3-4 months following delivery, and levels of YKL-40 and interleukin 6 (IL-6; known to regulate YKL-40) were measured. Plasma YKL-40 levels were similarly low during pregnancy in both groups and increased significantly after delivery, but remained lower in the GDM group compared with the non-GDM group postpartum. In contrast, plasma IL-6 levels were not affected by pregnancy or diagnosis of GDM, Nevertheless, YKL-40 levels were associated with IL-6 levels in the non-GDM group (but not in the GDM group). Pregnancy seems to be associated with a temporary reduction in circulating YKL-40, which increases after delivery, but to a much lesser extent in women with GDM than in non-GDM women.
妊娠期糖尿病（GDM）的特征是孕期出现高血糖。GDM发生时的临床情况使患者有很高的后续发生2型糖尿病的风险。炎症标志物YKL - 40的血浆水平在2型糖尿病中升高，并且与2型糖尿病患者的空腹血糖水平和胰岛素抵抗相关。在本研究中，我们旨在确定妊娠（以及相关的胰岛素抵抗）伴或不伴GDM是否会影响血浆YKL - 40水平。在妊娠晚期以及分娩后3 - 4个月获取被诊断为GDM的女性和健康糖耐量正常的孕妇（非GDM）的血浆，并测量YKL - 40和白细胞介素6（IL - 6；已知可调节YKL - 40）的水平。两组在孕期血浆YKL - 40水平均同样较低，分娩后显著升高，但产后GDM组仍低于非GDM组。相比之下，血浆IL - 6水平不受妊娠或GDM诊断的影响。然而，在非GDM组中YKL - 40水平与IL - 6水平相关（但在GDM组中不相关）。妊娠似乎与循环YKL - 40的暂时降低有关，分娩后该水平会升高，但GDM女性升高的程度远小于非GDM女性。
