Begley Dale A, Sundberg John P, Krupke Debra M, Neuhauser Steven B, Bult Carol J, Eppig Janan T, Morse Herbert C, Ward Jerrold M
The Jackson Laboratory, Bar Harbor, ME USA.
The Jackson Laboratory, Bar Harbor, ME USA.
Exp Mol Pathol. 2015 Dec;99(3):533-6. doi: 10.1016/j.yexmp.2015.07.004. Epub 2015 Aug 21.
Many mouse models have been created to study hematopoietic cancer types. There are over thirty hematopoietic tumor types and subtypes, both human and mouse, with various origins, characteristics and clinical prognoses. Determining the specific type of hematopoietic lesion produced in a mouse model and identifying mouse models that correspond to the human subtypes of these lesions has been a continuing challenge for the scientific community. The Mouse Tumor Biology Database (MTB; http://tumor.informatics.jax.org) is designed to facilitate use of mouse models of human cancer by providing detailed histopathologic and molecular information on lymphoma subtypes, including expertly annotated, on line, whole slide scans, and providing a repository for storing information on and querying these data for specific lymphoma models.
为了研究造血系统癌症类型，人们创建了许多小鼠模型。人类和小鼠的造血肿瘤类型及亚型有三十多种，它们有着不同的起源、特征和临床预后。确定小鼠模型中产生的造血病变的具体类型，并识别与这些病变的人类亚型相对应的小鼠模型，一直是科学界面临的挑战。小鼠肿瘤生物学数据库（MTB；http://tumor.informatics.jax.org）旨在通过提供淋巴瘤亚型的详细组织病理学和分子信息，包括经过专业注释的在线全玻片扫描，来促进人类癌症小鼠模型的使用，并提供一个存储和查询特定淋巴瘤模型信息的资源库。
