Ramírez María Soledad, Müller Gabriela Leticia, Pérez Jorgelina Fernanda, Golic Adrián Ezequiel, Mussi María Alejandra
Facultad de Ciencias Médicas, Instituto de Investigaciones en Microbiología y Parasitología Médica (IMPaM-CONICET), Universidad de Buenos Aires, Buenos Aires, Argentina.
Department of Biological Science, Center for Applied Biotechnology Studies, California State University Fullerton, Fullerton, CA.
Photochem Photobiol. 2015 Nov;91(6):1291-301. doi: 10.1111/php.12523. Epub 2015 Oct 24.
A summary of the major findings concerning light modulation in Acinetobacter baumannii, which governs aspects related to the success of this microorganism as a nosocomial pathogen, is presented. Particularly, the evidence shows that light modulates the ability of the bacteria to persist in the environment, its virulence against eukaryotic hosts and even susceptibility to certain antibiotics. The light signal is sensed through different mechanisms, in some cases involving specialized photoreceptors of the BLUF-type, whereas in others, directly by a photosensitizer molecule. We also provide new data concerning the genomic context of BLUF-domain containing proteins within the genus Acinetobacter, as well as further insights into the mechanism of light-mediated reduction in susceptibility to antibiotics. The overall information points toward light being a crucial stimulus in the lifestyle of members of the genus Acinetobacter as well as in other clinically relevant species, such as members of the ESKAPE group, playing therefore an important role in the clinical settings.
本文总结了鲍曼不动杆菌中光调节的主要发现，这些发现与这种微生物作为医院病原体的成功因素相关。具体而言，证据表明光可调节细菌在环境中持续存在的能力、其对真核宿主的毒力以及对某些抗生素的敏感性。光信号通过不同机制被感知，在某些情况下涉及BLUF型的专门光感受器，而在其他情况下则直接由光敏剂分子感知。我们还提供了有关不动杆菌属中含BLUF结构域蛋白的基因组背景的新数据，以及对光介导的抗生素敏感性降低机制的进一步见解。总体信息表明，光在不动杆菌属成员以及其他临床相关物种（如ESKAPE组的成员）的生活方式中是一种关键刺激因素，因此在临床环境中发挥着重要作用。
