Quéro Laurent, Guillerm Sophie, Hennequin Christophe
Laurent Quéro, Sophie Guillerm, Christophe Hennequin, Department of Radiation Oncology, Saint Louis Hospital, 75010 Paris, France.
World J Gastrointest Oncol. 2015 Aug 15;7(8):102-10. doi: 10.4251/wjgo.v7.i8.102.
Currently, there is no international consensus on the best treatment regimen for patients with advanced resectable gastric carcinoma. In the United States, where a limited lymph-node dissection is frequently performed, adjuvant chemoradiotherapy after surgery is the standard treatment. In Europe, intensified perioperative chemotherapy is commonly administered. In Japan and South Korea, postoperative S-1-based adjuvant chemotherapy after surgery with D2 lymph-node dissection is the standard treatment. Several ongoing trials are currently evaluating the optimal sequence of chemotherapy, radiotherapy, and surgery, as well as the place of targeted therapeutic agents in the treatment of advanced gastric carcinoma.
目前，对于晚期可切除胃癌患者的最佳治疗方案，国际上尚未达成共识。在美国，由于经常进行有限的淋巴结清扫，术后辅助放化疗是标准治疗方法。在欧洲，通常采用强化围手术期化疗。在日本和韩国，D2淋巴结清扫术后基于S-1的术后辅助化疗是标准治疗方法。目前有几项正在进行的试验正在评估化疗、放疗和手术的最佳顺序，以及靶向治疗药物在晚期胃癌治疗中的地位。
