Zhang Haiyan, Li Guang, Zhang Zhen
Gynaecology Ward-1 and Linyi City People's Hospital Linyi 276000, Shandong Province, China.
Gastrointestinal Surgery, Linyi City People's Hospital Linyi 276000, Shandong Province, China.
Int J Clin Exp Med. 2015 Jun 15;8(6):9135-41. eCollection 2015.
Hepatocarcinogenesis is a complex process that is influenced by many factors. Several studies have investigated the relationship between MTHFR A1298C polymorphism and hepatocellular carcinoma (HCC) risk, but the results are inconsistent. Therefore, we performed a meta-analysis covering a large sample size to address this controversy.
Eligible studies were searched using PubMed, EMBASE, and China National Knowledge Infrastructure (CNKI) databases. A total of 7 studies from 6 publications with 2035 cases and 3096 controls were included. The pooled odds ratios (ORs) with 95% confidence intervals (CIs) was calculated by the fixed or random effects to evaluate the correlation between MTHFR A1298C polymorphism and HCC risk. The Q statistic and I(2) statistic were used to assess the statistical heterogeneity among studies. Publication bias was evaluated by Egger's linear regression test and Begg's funnel plot.
In present study, the results showed that MTHFR A1298C polymorphism was not significantly associated with risk of HCC based on CC + AC vs. AA genetic model (OR=1.01, 95% CI=0.90-1.13). Similarly, in the subgroup analysis by ethnicity, no significant HCC risk was found in Asian population (OR=1.02, 95% CI=0.91-1.14). In the subgroup analysis based on source of control, we found that MTHFR A1298C polymorphism showed no effects on the occurrence of HCC in the population-based (PB) and hospital-based (HB) group (OR=0.97, 95% CI=0.83-1.15; OR=1.04, 95% CI=0.89-1.21).
This meta-analysis suggested that MTHFR A1298C polymorphism may not be a risk factor for HCC.
肝癌发生是一个受多种因素影响的复杂过程。多项研究探讨了亚甲基四氢叶酸还原酶（MTHFR）A1298C基因多态性与肝细胞癌（HCC）风险之间的关系，但结果并不一致。因此，我们进行了一项大样本量的荟萃分析以解决这一争议。
通过检索PubMed、EMBASE和中国知网（CNKI）数据库来查找符合条件的研究。共纳入6篇出版物中的7项研究，包括2035例病例和3096例对照。采用固定效应或随机效应模型计算合并比值比（OR）及95%置信区间（CI），以评估MTHFR A1298C基因多态性与HCC风险之间的相关性。使用Q统计量和I²统计量评估研究间的统计学异质性。通过Egger线性回归检验和Begg漏斗图评估发表偏倚。
在本研究中，结果显示基于CC + AC与AA基因模型，MTHFR A1298C基因多态性与HCC风险无显著相关性（OR = 1.01，95%CI = 0.90 - 1.13）。同样，在按种族进行的亚组分析中，亚洲人群未发现显著的HCC风险（OR = 1.02，95%CI = 0.91 - 1.14）。在基于对照来源的亚组分析中，我们发现MTHFR A1298C基因多态性在基于人群（PB）和基于医院（HB）的组中对HCC的发生均无影响（OR = 0.97，95%CI = 0.83 - 1.15；OR = 1.04，95%CI = 0.89 - 1.21）。
这项荟萃分析表明，MTHFR A1298C基因多态性可能不是HCC的危险因素。
