钯催化的烯酰胺氢炔基化反应中N-取代基依赖性立体选择性开关：烯炔酰胺的区域和立体选择性合成

N-Substitution dependent stereoselectivity switch in palladium catalyzed hydroalkynylation of ynamides: a regio and stereoselective synthesis of ynenamides.

作者信息

Dwivedi Vikas, Babu Madala Hari, Kant Ruchir, Reddy Maddi Sridhar

机构信息

Medicinal & Process Chemistry Division, CSIR-Central Drug Research Institute, BS-10/1, Sector 10, Jankipuram extension, Sitapur Road, Lucknow 226031, India.

出版信息

Chem Commun (Camb). 2015 Oct 18;51(81):14996-9. doi: 10.1039/c5cc06251a.

DOI:10.1039/c5cc06251a

PMID:26310917

Abstract

A highly general palladium catalysed regioselective hydroalkynylation of ynamides for versatile enamide building blocks with an alkyne tether is achieved with an N-substitution dependent stereoselectivity switch under very mild reaction conditions.

摘要

在非常温和的反应条件下，通过N-取代依赖性立体选择性开关，实现了一种高度通用的钯催化的烯酰胺与炔烃连接的多功能烯酰胺结构单元的区域选择性氢炔基化反应。