Neckař Pavel, Syková Eva
Cas Lek Cesk. 2015;154(3):107-9.
Sharing new ideas and approaches is needed to advance basic scientific research as well as the clinical application of stem cells. In this newsletter we present the current knowledge in stem cell research and therapy within the field of orthopaedics, presenting the definitions, types and sources of the stem cells. The second part of this newsletter focuses on the clinical application of stem cells in the therapy of tissues with very limited capacity for self-regeneration; this includes tendons and ligaments, particularly found in rotator cuff rupture. The sever problems associated with articular cartilage repair have lead to the need for the development of clinical research, with the aim of finding efficient clinical applications of stem cell therapy in cartilage defects and osteoarthritis. However in addition to this, such therapy could be used for the regeneration of bone, as in bone defect repair. The clinical outcome of stem cell therapy is a promising option for the treatment of cartilage, bone and tendon defects; however an increased sample size and additional long-term prospective randomised studies are needed to confirm these preliminary results.
分享新思想和新方法对于推进基础科学研究以及干细胞的临床应用至关重要。在本通讯中，我们介绍了骨科领域干细胞研究与治疗的当前知识，阐述了干细胞的定义、类型和来源。本通讯的第二部分聚焦于干细胞在自我修复能力非常有限的组织治疗中的临床应用，这包括肌腱和韧带，尤其是在肩袖撕裂中发现的情况。与关节软骨修复相关的严重问题导致了开展临床研究的必要性，目的是找到干细胞疗法在软骨缺损和骨关节炎中的有效临床应用。然而除此之外，这种疗法还可用于骨再生，比如骨缺损修复。干细胞疗法的临床结果对于治疗软骨、骨和肌腱缺损是一个有前景的选择；然而需要增加样本量并开展更多长期前瞻性随机研究来证实这些初步结果。
