Crissman J D
Head Neck Surg. 1979 May-Jun;1(5):386-91. doi: 10.1002/hed.2890010503.
The frequency with which carcinoma develops in laryngeal keratoses is a controversial subject. A study of 92 cases of laryngeal keratosis with a minimum of five years' follow-up resulted in identification of three patients (3.26%) who developed laryngeal carcinoma. A reviews of the literature reveals that, in series of keratoses defined by stringent pathologic criteria, subsequent laryngeal carcinoma develops in 3.33%-4.31%. These findings support a low but predictable frequency of conversion to malignancy in laryngeal keratosis. A grading system for keratosis is presented and discussed with reference to clinicopathologic correlation.
喉角化病发展为癌的频率是一个有争议的话题。一项对92例喉角化病患者进行的至少为期五年的随访研究发现，有三名患者（3.26%）发展为喉癌。文献综述显示，在符合严格病理标准的角化病系列病例中，后续发生喉癌的比例为3.33%-4.31%。这些发现支持了喉角化病发展为恶性肿瘤的频率较低但可预测的观点。本文提出并讨论了一种关于角化病的分级系统，并参考了临床病理相关性。
