辅酶Q10在神经退行性疾病中的神经保护作用

Neuroprotection of Coenzyme Q10 in Neurodegenerative Diseases.

作者信息

Yang Xifei, Zhang Yanling, Xu Hua, Luo Xiaobin, Yu Jun, Liu Jianjun, Chang Raymond Chuen-Chung

机构信息

Key Laboratory of Modern Toxicology of Shenzhen, Medical Key Laboratory of Guangdong Province, Medical Key Laboratory of Health Toxicology of Shenzhen, Shenzhen Center for Disease Control and Prevention, Shenzhen, 518055, China.

出版信息

Curr Top Med Chem. 2016;16(8):858-66. doi: 10.2174/1568026615666150827095252.

DOI:10.2174/1568026615666150827095252

PMID:26311425

Abstract

Coenzyme Q10 (CoQ10) is a component of electron transport chain and acts as an antioxidant. It is also used for preventing neurodegeneration against mitochondrial deficiency and oxidative stress. Therefore, CoQ10 has received increasing attention as therapeutic and preventive intervention for neurodegenerative diseases. This review article focuses mainly on the structure of CoQ10, the function of CoQ10 and the relationship between mitochondrial impairment, oxidative stress and neurodegenerative diseases. In addition, the effects of CoQ10 on Alzheimer's disease, Parkinson's disease, and Huntington's disease are also discussed. Finally, future perspectives regarding development of successful treatment for neurodegenerative diseases are proposed.

摘要

辅酶Q10（CoQ10）是电子传递链的一个组成部分，起抗氧化剂的作用。它还用于预防因线粒体缺陷和氧化应激导致的神经退行性变。因此，辅酶Q10作为神经退行性疾病的治疗和预防干预措施受到了越来越多的关注。这篇综述文章主要关注辅酶Q10的结构、辅酶Q10的功能以及线粒体损伤、氧化应激与神经退行性疾病之间的关系。此外，还讨论了辅酶Q10对阿尔茨海默病、帕金森病和亨廷顿病的影响。最后，提出了关于成功治疗神经退行性疾病的未来展望。