Huang Yeqian, Alzahrani Nayef A, Alzahrani Saleh E, Zhao Jing, Liauw Winston, Morris David L
St George Clinical School, University of New South Wales, St George Hospital, New South Wales, Australia.
Department of Surgery, University of New South Wales, St George Hospital, New South Wales, Australia.
World J Surg Oncol. 2015 Aug 28;13:262. doi: 10.1186/s12957-015-0682-7.
Peritoneal carcinomatosis is life-threatening without cytoreductive surgery (CRS) and perioperative intraperitoneal chemotherapy (PIC). Only a few studies in the literature addressed the relationship between age and outcomes of peritonectomy. This study was designed to review the clinical outcomes in elderly patients who underwent CRS and PIC.
This is a retrospective study of prospectively collected data of 611 consecutive patients with peritoneal carcinomatosis who underwent CRS and PIC by the same surgical team at St George Hospital in Sydney, Australia, between January 1996 and December 2013. Patients were divided into two groups; group 1 (<65 years old, n = 487) and group 2 (≥ 65 years old, n = 124). Subgroup analysis was performed in patients who were ≥75 years old (n = 20). A significant difference was defined as p < 0.05.
There was no significant statistical difference in terms of mean total hospital stay, intensive care unit stay, high dependency unit stay and complication rates. Postoperative mortality was 2 and 3 % in groups 1 and 2, respectively. Overall survival did not reach a statistical significance between the two groups. In subgroup analysis, patients showed similar morbidity results to patients who were <65 years old.
CRS and PIC can be safely done in the elderly. Age alone should not be the single exclusion criterion but rather taken into consideration along with other factors to determine the suitability of elderly patients.
腹膜癌若不进行细胞减灭术（CRS）及围手术期腹腔内化疗（PIC）会危及生命。文献中仅有少数研究探讨了年龄与腹膜切除术预后之间的关系。本研究旨在回顾接受CRS和PIC的老年患者的临床结局。
这是一项回顾性研究，对1996年1月至2013年12月期间在澳大利亚悉尼圣乔治医院由同一手术团队连续收治的611例腹膜癌患者的前瞻性收集数据进行分析。患者分为两组；第1组（<65岁，n = 487）和第2组（≥65岁，n = 124）。对年龄≥75岁的患者（n = 20）进行亚组分析。差异有统计学意义定义为p < 0.05。
在平均总住院时间、重症监护病房住院时间、高依赖病房住院时间和并发症发生率方面，无显著统计学差异。第1组和第2组的术后死亡率分别为2%和3%。两组间总生存率未达到统计学意义。在亚组分析中，患者的发病率结果与<65岁的患者相似。
老年患者可安全地进行CRS和PIC。年龄不应单独作为唯一的排除标准，而应与其他因素一起考虑，以确定老年患者的适用性。
