丙磺舒和苯溴马隆对分离的大鼠肝细胞糖异生的影响。
Effect of probenecid and benzbromarone on gluconeogenesis in isolated rat liver cells.
作者信息
Rodilla F, Sánchez-Beltrán M J, Izquierdo R, Gómez-Ruiz M D, Cabo J
机构信息
Departamento de Bioquímica y Biología Molecular, Facultad de Farmacia, Universidad de Valencia, Spain.
出版信息
Rev Esp Fisiol. 1989 Dec;45(4):391-4.
The effect of benzbromarone on gluconeogenesis from several gluconeogenic substrates in isolated rat liver cells is reported. Benzbromarone inhibited glucose synthesis from all substrates employed when the drug was used at concentrations half to ten times greater than its therapeutic plasma levels. This inhibition was more pronounced from lactate and pyruvate than from fructose and glycerol. The results are compared with those obtained for probenecid, a classical uricosuric drug. We found that probenecid inhibited the pathway in the same way as benzbromarone.
本文报道了苯溴马隆对离体大鼠肝细胞中几种糖异生底物糖异生作用的影响。当苯溴马隆的使用浓度高于其治疗血浆水平的一半至十倍时，它能抑制所有所使用底物的葡萄糖合成。这种抑制作用在乳酸和丙酮酸上比在果糖和甘油上更为明显。将这些结果与经典排尿酸药丙磺舒的结果进行了比较。我们发现丙磺舒对该途径的抑制作用与苯溴马隆相同。
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